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Stepwise Application of Urine Markers to Detect Tumor Recurrence in Patients Undergoing Surveillance for Non-Muscle-Invasive Bladder Cancer
المؤلفون المشاركون
Gakis, Georgios
Hennenlotter, Jörg
Kuehs, Ursula
Schwentner, Christian
Todenhöfer, Tilman
Esser, Michael
Mohrhardt, Sarah
Aufderklamm, Stefan
Böttge, Johannes
Rausch, Steffen
Mischinger, Johannes
Bier, Simone
Stenzl, Arnulf
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-12-22
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Background.
The optimal use of urine markers in the surveillance of non-muscle-invasive bladder cancer (NMIBC) remains unclear.
Aim of the present study was to investigate the combined and stepwise use of the four most broadly available urine markers to detect tumor recurrence in patients undergoing surveillance of NMIBC.
Patients and Methods.
483 patients with history of NMIBC were included.
Cytology, UroVysion, fluorescence in situ hybridization (FISH), immunocytology (uCyt+), and NMP22 ELISA were performed before surveillance cystoscopy.
Characteristics of single tests and combinations were assessed by contingency analysis.
Results.
128 (26.5%) patients had evidence of tumor recurrence.
Sensitivities and negative predictive values (NPVs) of the single tests ranged between 66.4–74.3 and 82.3–88.2%.
Two-marker combinations showed sensitivities and NPVs of 80.5–89.8 and 89.5–91.2%.
A stepwise application of the two-test combinations with highest accuracy (cytology and FISH; cytology and uCyt+; uCyt+ and FISH) showed NPVs for high-risk recurrences (G3/Cis/pT1) of 98.8, 98.8, and 99.1%, respectively.
Conclusions.
Combinations of cytology, FISH, immunocytology, and NMP22 show remarkable detection rates for recurrent NMIBC.
Stepwise two-test combinations of cytology, FISH, and immunocytology have a low probability of missing a high-risk tumor.
The high sensitivities may justify the use of these combinations in prospective studies assessing the use of urine markers to individualize intervals between cystoscopies during follow-up.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Todenhöfer, Tilman& Hennenlotter, Jörg& Esser, Michael& Mohrhardt, Sarah& Aufderklamm, Stefan& Böttge, Johannes…[et al.]. 2014. Stepwise Application of Urine Markers to Detect Tumor Recurrence in Patients Undergoing Surveillance for Non-Muscle-Invasive Bladder Cancer. Disease Markers،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1035071
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Todenhöfer, Tilman…[et al.]. Stepwise Application of Urine Markers to Detect Tumor Recurrence in Patients Undergoing Surveillance for Non-Muscle-Invasive Bladder Cancer. Disease Markers No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-1035071
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Todenhöfer, Tilman& Hennenlotter, Jörg& Esser, Michael& Mohrhardt, Sarah& Aufderklamm, Stefan& Böttge, Johannes…[et al.]. Stepwise Application of Urine Markers to Detect Tumor Recurrence in Patients Undergoing Surveillance for Non-Muscle-Invasive Bladder Cancer. Disease Markers. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1035071
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1035071
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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