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Stepwise Application of Urine Markers to Detect Tumor Recurrence in Patients Undergoing Surveillance for Non-Muscle-Invasive Bladder Cancer
Joint Authors
Gakis, Georgios
Hennenlotter, Jörg
Kuehs, Ursula
Schwentner, Christian
Todenhöfer, Tilman
Esser, Michael
Mohrhardt, Sarah
Aufderklamm, Stefan
Böttge, Johannes
Rausch, Steffen
Mischinger, Johannes
Bier, Simone
Stenzl, Arnulf
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-12-22
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background.
The optimal use of urine markers in the surveillance of non-muscle-invasive bladder cancer (NMIBC) remains unclear.
Aim of the present study was to investigate the combined and stepwise use of the four most broadly available urine markers to detect tumor recurrence in patients undergoing surveillance of NMIBC.
Patients and Methods.
483 patients with history of NMIBC were included.
Cytology, UroVysion, fluorescence in situ hybridization (FISH), immunocytology (uCyt+), and NMP22 ELISA were performed before surveillance cystoscopy.
Characteristics of single tests and combinations were assessed by contingency analysis.
Results.
128 (26.5%) patients had evidence of tumor recurrence.
Sensitivities and negative predictive values (NPVs) of the single tests ranged between 66.4–74.3 and 82.3–88.2%.
Two-marker combinations showed sensitivities and NPVs of 80.5–89.8 and 89.5–91.2%.
A stepwise application of the two-test combinations with highest accuracy (cytology and FISH; cytology and uCyt+; uCyt+ and FISH) showed NPVs for high-risk recurrences (G3/Cis/pT1) of 98.8, 98.8, and 99.1%, respectively.
Conclusions.
Combinations of cytology, FISH, immunocytology, and NMP22 show remarkable detection rates for recurrent NMIBC.
Stepwise two-test combinations of cytology, FISH, and immunocytology have a low probability of missing a high-risk tumor.
The high sensitivities may justify the use of these combinations in prospective studies assessing the use of urine markers to individualize intervals between cystoscopies during follow-up.
American Psychological Association (APA)
Todenhöfer, Tilman& Hennenlotter, Jörg& Esser, Michael& Mohrhardt, Sarah& Aufderklamm, Stefan& Böttge, Johannes…[et al.]. 2014. Stepwise Application of Urine Markers to Detect Tumor Recurrence in Patients Undergoing Surveillance for Non-Muscle-Invasive Bladder Cancer. Disease Markers،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1035071
Modern Language Association (MLA)
Todenhöfer, Tilman…[et al.]. Stepwise Application of Urine Markers to Detect Tumor Recurrence in Patients Undergoing Surveillance for Non-Muscle-Invasive Bladder Cancer. Disease Markers No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-1035071
American Medical Association (AMA)
Todenhöfer, Tilman& Hennenlotter, Jörg& Esser, Michael& Mohrhardt, Sarah& Aufderklamm, Stefan& Böttge, Johannes…[et al.]. Stepwise Application of Urine Markers to Detect Tumor Recurrence in Patients Undergoing Surveillance for Non-Muscle-Invasive Bladder Cancer. Disease Markers. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1035071
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1035071