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Effects of Chinese Medicine Tong xinluo on Diabetic Nephropathy via Inhibiting TGF-β1-Induced Epithelial-to-Mesenchymal Transition
المؤلفون المشاركون
Wang, Jin-Yang
Gao, Yan-Bin
Li, Jiaoyang
Zhou, Shengnan
Zhao, Xuan
Xu, Liping
Zhang, Haiyan
Zou, Da-Wei
Zhu, Zhi-Yao
Zhang, Na
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-04-17
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Diabetic nephropathy (DN) is a major cause of chronic kidney failure and characterized by interstitial and glomeruli fibrosis.
Epithelial-to-mesenchymal transition (EMT) plays an important role in the pathogenesis of DN.
Tong xinluo (TXL), a Chinese herbal compound, has been used in China with established therapeutic efficacy in patients with DN.
To investigate the molecular mechanism of TXL improving DN, KK-Ay mice were selected as models for the evaluation of pathogenesis and treatment in DN.
In vitro, TGF-β1 was used to induce EMT.
Western blot (WB), immunofluorescence staining, and real-time polymerase chain reaction (RT-PCR) were applied to detect the changes of EMT markers in vivo and in vitro, respectively.
Results showed the expressions of TGF-β1 and its downstream proteins smad3/p-smad3 were greatly reduced in TXL group; meantime, TXL restored the expression of smad7.
As a result, the expressions of collagen IV (Col IV) and fibronectin (FN) were significantly decreased in TXL group.
In vivo, 24 h-UAER (24-hour urine albumin excretion ratio) and BUN (blood urea nitrogen) were decreased and Ccr (creatinine clearance ratio) was increased in TXL group compared with DN group.
In summary, the present study demonstrates that TXL successfully inhibits TGF-β1-induced epithelial-to-mesenchymal transition in DN, which may account for the therapeutic efficacy in TXL-mediated renoprotection.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhang, Na& Gao, Yan-Bin& Zou, Da-Wei& Wang, Jin-Yang& Li, Jiaoyang& Zhou, Shengnan…[et al.]. 2014. Effects of Chinese Medicine Tong xinluo on Diabetic Nephropathy via Inhibiting TGF-β1-Induced Epithelial-to-Mesenchymal Transition. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-1035096
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhang, Na…[et al.]. Effects of Chinese Medicine Tong xinluo on Diabetic Nephropathy via Inhibiting TGF-β1-Induced Epithelial-to-Mesenchymal Transition. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-12.
https://search.emarefa.net/detail/BIM-1035096
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhang, Na& Gao, Yan-Bin& Zou, Da-Wei& Wang, Jin-Yang& Li, Jiaoyang& Zhou, Shengnan…[et al.]. Effects of Chinese Medicine Tong xinluo on Diabetic Nephropathy via Inhibiting TGF-β1-Induced Epithelial-to-Mesenchymal Transition. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-1035096
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1035096
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
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