Cognitive-Enhancing Effect of Steamed and Fermented Codonopsis lanceolata: A Behavioral and Biochemical Study
المؤلفون المشاركون
Chung, Jae Youn
Eom, Min Rye
Ma, Choong Je
Chung, Hee-Chul
Lee, Jiwoo
Ko, Hyun-Jeong
Yun, Bo-Ra
Weon, Jin Bae
Park, Dong-Sik
Lee, Hyeon Yong
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-06-16
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by memory impairment.
Codonopsis lanceolata (C.
lanceolata) has been employed clinically for lung inflammatory diseases such as asthma, tonsillitis, and pharyngitis.
The present study was undertaken to evaluate the effect of fermented C.
lanceolata (300, 500, and 800 mg/kg) on learning and memory impairment induced by scopolamine by using the Morris water maze and passive avoidance tests.
To elucidate possible mechanism of cognitive-enhancing activity, we measured acetylcholinesterase (AchE) activity, brain-derived neurotrophic factor (BDNF), and cyclic AMP response element-binding protein (CREB) expression in the brain of mice.
Administration of fermented C.
lanceolata (800 mg/kg) led to reduced scopolamine-induced memory impairment in the Morris water maze and passive avoidance tests.
Accordingly, the administration of fermented C.
lanceolata inhibited AchE activity.
Interestingly, the level of CREB phosphorylation and BDNF expression in hippocampal tissue of scopolamine-treated mice was significantly increased by the administration of fermented C.
lanceolata.
These results indicate that fermented C.
lanceolata can ameliorate scopolamine-induced memory deficits in mouse and may be an alternative agent for the treatment of AD.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Weon, Jin Bae& Yun, Bo-Ra& Lee, Jiwoo& Eom, Min Rye& Ko, Hyun-Jeong& Lee, Hyeon Yong…[et al.]. 2014. Cognitive-Enhancing Effect of Steamed and Fermented Codonopsis lanceolata: A Behavioral and Biochemical Study. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1035153
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Weon, Jin Bae…[et al.]. Cognitive-Enhancing Effect of Steamed and Fermented Codonopsis lanceolata: A Behavioral and Biochemical Study. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-1035153
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Weon, Jin Bae& Yun, Bo-Ra& Lee, Jiwoo& Eom, Min Rye& Ko, Hyun-Jeong& Lee, Hyeon Yong…[et al.]. Cognitive-Enhancing Effect of Steamed and Fermented Codonopsis lanceolata: A Behavioral and Biochemical Study. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1035153
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1035153
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر