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Cognitive-Enhancing Effect of Steamed and Fermented Codonopsis lanceolata: A Behavioral and Biochemical Study
Joint Authors
Chung, Jae Youn
Eom, Min Rye
Ma, Choong Je
Chung, Hee-Chul
Lee, Jiwoo
Ko, Hyun-Jeong
Yun, Bo-Ra
Weon, Jin Bae
Park, Dong-Sik
Lee, Hyeon Yong
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-16
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by memory impairment.
Codonopsis lanceolata (C.
lanceolata) has been employed clinically for lung inflammatory diseases such as asthma, tonsillitis, and pharyngitis.
The present study was undertaken to evaluate the effect of fermented C.
lanceolata (300, 500, and 800 mg/kg) on learning and memory impairment induced by scopolamine by using the Morris water maze and passive avoidance tests.
To elucidate possible mechanism of cognitive-enhancing activity, we measured acetylcholinesterase (AchE) activity, brain-derived neurotrophic factor (BDNF), and cyclic AMP response element-binding protein (CREB) expression in the brain of mice.
Administration of fermented C.
lanceolata (800 mg/kg) led to reduced scopolamine-induced memory impairment in the Morris water maze and passive avoidance tests.
Accordingly, the administration of fermented C.
lanceolata inhibited AchE activity.
Interestingly, the level of CREB phosphorylation and BDNF expression in hippocampal tissue of scopolamine-treated mice was significantly increased by the administration of fermented C.
lanceolata.
These results indicate that fermented C.
lanceolata can ameliorate scopolamine-induced memory deficits in mouse and may be an alternative agent for the treatment of AD.
American Psychological Association (APA)
Weon, Jin Bae& Yun, Bo-Ra& Lee, Jiwoo& Eom, Min Rye& Ko, Hyun-Jeong& Lee, Hyeon Yong…[et al.]. 2014. Cognitive-Enhancing Effect of Steamed and Fermented Codonopsis lanceolata: A Behavioral and Biochemical Study. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1035153
Modern Language Association (MLA)
Weon, Jin Bae…[et al.]. Cognitive-Enhancing Effect of Steamed and Fermented Codonopsis lanceolata: A Behavioral and Biochemical Study. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-1035153
American Medical Association (AMA)
Weon, Jin Bae& Yun, Bo-Ra& Lee, Jiwoo& Eom, Min Rye& Ko, Hyun-Jeong& Lee, Hyeon Yong…[et al.]. Cognitive-Enhancing Effect of Steamed and Fermented Codonopsis lanceolata: A Behavioral and Biochemical Study. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1035153
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1035153