Inhibitory Effects of Gymnema (Gymnema sylvestre)‎ Leaves on Tumour Promotion in Two-Stage Mouse Skin Carcinogenesis

الملخص EN

Ethanol extracts of gymnema (Gymnema sylvestre) leaves exhibited marked antitumour-promoting activity in an in vivo two-stage carcinogenesis test in mice using 7,12-dimethylbenz[a]anthracene as an initiator and 12-O-tetradecanoylphorbol-13-acetate (TPA) as a promoter.

From the active fraction of the ethanol extract of the gymnema leaves, three triterpenoids were isolated and identified.

These compounds were evaluated for their inhibitory effects on TPA-induced inflammation (1 µg/ear) in mice.

The tested compounds showed marked anti-inflammatory effects, with a 50% inhibitory dose of 50–555 nmol/ear.