Inhibitory Effects of Gymnema (Gymnema sylvestre) Leaves on Tumour Promotion in Two-Stage Mouse Skin Carcinogenesis
Joint Authors
Okuda, Sakiko
Nobushi, Yasuhito
Yasukawa, Ken
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-03-06
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Ethanol extracts of gymnema (Gymnema sylvestre) leaves exhibited marked antitumour-promoting activity in an in vivo two-stage carcinogenesis test in mice using 7,12-dimethylbenz[a]anthracene as an initiator and 12-O-tetradecanoylphorbol-13-acetate (TPA) as a promoter.
From the active fraction of the ethanol extract of the gymnema leaves, three triterpenoids were isolated and identified.
These compounds were evaluated for their inhibitory effects on TPA-induced inflammation (1 µg/ear) in mice.
The tested compounds showed marked anti-inflammatory effects, with a 50% inhibitory dose of 50–555 nmol/ear.
American Psychological Association (APA)
Yasukawa, Ken& Okuda, Sakiko& Nobushi, Yasuhito. 2014. Inhibitory Effects of Gymnema (Gymnema sylvestre) Leaves on Tumour Promotion in Two-Stage Mouse Skin Carcinogenesis. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-1035158
Modern Language Association (MLA)
Yasukawa, Ken…[et al.]. Inhibitory Effects of Gymnema (Gymnema sylvestre) Leaves on Tumour Promotion in Two-Stage Mouse Skin Carcinogenesis. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-5.
https://search.emarefa.net/detail/BIM-1035158
American Medical Association (AMA)
Yasukawa, Ken& Okuda, Sakiko& Nobushi, Yasuhito. Inhibitory Effects of Gymnema (Gymnema sylvestre) Leaves on Tumour Promotion in Two-Stage Mouse Skin Carcinogenesis. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-1035158
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1035158
