Yi Qi Qing Re Gao Attenuates Podocyte Injury and Inhibits Vascular Endothelial Growth Factor Overexpression in Puromycin Aminonucleoside Rat Model
المؤلفون المشاركون
Zhang, Haojun
Zhan, Yongli
Yang, Liping
Wen, Yumin
Liu, Huijie
Zhu, Bin
Han, Wenbing
Gu, Yanting
Sun, Xueyan
Dong, Xi
Zhao, Tingting
Ma, Huixia
Li, Ping
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-05-21
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
Proteinuria is the hallmark of chronic kidney disease.
Podocyte damage underlies the formation of proteinuria, and vascular endothelial growth factor (VEGF) functions as an autocrine/paracrine regulator.
Yi Qi Qing Re Gao (YQQRG) has been used to treat proteinuria for more than two decades.
The objective of this study was to investigate the protective effect and possible mechanisms of YQQRG on puromycin aminonucleoside (PAN) rat model.
Eighty male Sprague-Dawley rats were randomized into sham group, PAN group, PAN + YQQRG group, and PAN + fosinopril group.
Treatments were started 7 days before induction of nephrosis (a single intravenous injection of 40 mg/kg PAN) until day 15.
24 h urinary samples were collected on days 5, 9, and 14.
The animals were sacrificed on days 3, 10, and 15, respectively.
Blood samples and renal tissues were obtained for detection of biochemical and molecular biological parameters.
YQQRG significantly reduced proteinuria, elevated serum albumin, and alleviated renal pathological lesions.
YQQRG inhibited VEGF-A, nephrin, podocin, and CD2AP mRNA expression and elevated nephrin, podocin, and CD2AP protein levels starting on day 3.
In conclusion, YQQRG attenuates podocyte injury in the rat PAN model through downregulation of VEGF-A and restoration of nephrin, podocin, and CD2AP protein expression.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhan, Yongli& Yang, Liping& Wen, Yumin& Liu, Huijie& Zhang, Haojun& Zhu, Bin…[et al.]. 2014. Yi Qi Qing Re Gao Attenuates Podocyte Injury and Inhibits Vascular Endothelial Growth Factor Overexpression in Puromycin Aminonucleoside Rat Model. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-1035173
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhan, Yongli…[et al.]. Yi Qi Qing Re Gao Attenuates Podocyte Injury and Inhibits Vascular Endothelial Growth Factor Overexpression in Puromycin Aminonucleoside Rat Model. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-13.
https://search.emarefa.net/detail/BIM-1035173
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhan, Yongli& Yang, Liping& Wen, Yumin& Liu, Huijie& Zhang, Haojun& Zhu, Bin…[et al.]. Yi Qi Qing Re Gao Attenuates Podocyte Injury and Inhibits Vascular Endothelial Growth Factor Overexpression in Puromycin Aminonucleoside Rat Model. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-1035173
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1035173
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر