Yi Qi Qing Re Gao Attenuates Podocyte Injury and Inhibits Vascular Endothelial Growth Factor Overexpression in Puromycin Aminonucleoside Rat Model
Joint Authors
Zhang, Haojun
Zhan, Yongli
Yang, Liping
Wen, Yumin
Liu, Huijie
Zhu, Bin
Han, Wenbing
Gu, Yanting
Sun, Xueyan
Dong, Xi
Zhao, Tingting
Ma, Huixia
Li, Ping
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-21
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Proteinuria is the hallmark of chronic kidney disease.
Podocyte damage underlies the formation of proteinuria, and vascular endothelial growth factor (VEGF) functions as an autocrine/paracrine regulator.
Yi Qi Qing Re Gao (YQQRG) has been used to treat proteinuria for more than two decades.
The objective of this study was to investigate the protective effect and possible mechanisms of YQQRG on puromycin aminonucleoside (PAN) rat model.
Eighty male Sprague-Dawley rats were randomized into sham group, PAN group, PAN + YQQRG group, and PAN + fosinopril group.
Treatments were started 7 days before induction of nephrosis (a single intravenous injection of 40 mg/kg PAN) until day 15.
24 h urinary samples were collected on days 5, 9, and 14.
The animals were sacrificed on days 3, 10, and 15, respectively.
Blood samples and renal tissues were obtained for detection of biochemical and molecular biological parameters.
YQQRG significantly reduced proteinuria, elevated serum albumin, and alleviated renal pathological lesions.
YQQRG inhibited VEGF-A, nephrin, podocin, and CD2AP mRNA expression and elevated nephrin, podocin, and CD2AP protein levels starting on day 3.
In conclusion, YQQRG attenuates podocyte injury in the rat PAN model through downregulation of VEGF-A and restoration of nephrin, podocin, and CD2AP protein expression.
American Psychological Association (APA)
Zhan, Yongli& Yang, Liping& Wen, Yumin& Liu, Huijie& Zhang, Haojun& Zhu, Bin…[et al.]. 2014. Yi Qi Qing Re Gao Attenuates Podocyte Injury and Inhibits Vascular Endothelial Growth Factor Overexpression in Puromycin Aminonucleoside Rat Model. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-1035173
Modern Language Association (MLA)
Zhan, Yongli…[et al.]. Yi Qi Qing Re Gao Attenuates Podocyte Injury and Inhibits Vascular Endothelial Growth Factor Overexpression in Puromycin Aminonucleoside Rat Model. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-13.
https://search.emarefa.net/detail/BIM-1035173
American Medical Association (AMA)
Zhan, Yongli& Yang, Liping& Wen, Yumin& Liu, Huijie& Zhang, Haojun& Zhu, Bin…[et al.]. Yi Qi Qing Re Gao Attenuates Podocyte Injury and Inhibits Vascular Endothelial Growth Factor Overexpression in Puromycin Aminonucleoside Rat Model. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-1035173
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1035173