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Evaluation of Blueberry Juice in Mouse Azoxymethane-Induced Aberrant Crypts and Oxidative Damage
المؤلفون المشاركون
Morales González, José A.
Madrigal-Santillán, Eduardo
Garcia-Melo, Fernando
Vásquez-Garzón, Verónica R.
Villa-Treviño, Saúl
Mendoza-Pérez, Jorge A.
Alvarez-González, Isela
Madrigal-Bujaidar, Eduardo
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-09-02
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Blueberry is a plant with a number of nutritional and biomedical capabilities.
In the present study we initially evaluated the capacity of its juice (BJ) to inhibit the number of aberrant crypts (AC) induced with azoxymethane (AOM) in mouse.
BJ was administered daily by the oral route to three groups of animals during four weeks (1.6, 4.1, and 15.0 μL/g), respectively, while AOM (10 mg/kg) was intraperitoneally injected to the mentioned groups, twice a week, in weeks two and three of the assay.
We also included two control groups of mice, one administered distilled water and the other the high dose of BJ.
A significant increase of AC was observed in the AOM treated animals, and a mean protection of 75.6% was determined with the two low doses of BJ tested; however, the high dose of the juice administered together with AOM increased the number of crypts more than four times the value observed in animals administered only AOM.
Furthermore, we determined the antioxidant potential of BJ with an ex vivo DPPH assay and found a dose-dependent decrease with a mean of 19.5%.
We also determined the DNA oxidation/antioxidation by identifying 8-hydroxy-2′-deoxyguanosine adducts and found a mean decrease of 44.3% with the BJ administration with respect to the level induced by AOM.
Our results show a complex differential effect of BJ related to the tested doses, opening the need to further evaluate a number of factors so as to determine the possibility of a cocarcinogenic potential.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Alvarez-González, Isela& Garcia-Melo, Fernando& Vásquez-Garzón, Verónica R.& Villa-Treviño, Saúl& Madrigal-Santillán, Eduardo& Morales González, José A.…[et al.]. 2014. Evaluation of Blueberry Juice in Mouse Azoxymethane-Induced Aberrant Crypts and Oxidative Damage. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1035176
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Alvarez-González, Isela…[et al.]. Evaluation of Blueberry Juice in Mouse Azoxymethane-Induced Aberrant Crypts and Oxidative Damage. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-1035176
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Alvarez-González, Isela& Garcia-Melo, Fernando& Vásquez-Garzón, Verónica R.& Villa-Treviño, Saúl& Madrigal-Santillán, Eduardo& Morales González, José A.…[et al.]. Evaluation of Blueberry Juice in Mouse Azoxymethane-Induced Aberrant Crypts and Oxidative Damage. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1035176
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1035176
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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