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Evaluation of Blueberry Juice in Mouse Azoxymethane-Induced Aberrant Crypts and Oxidative Damage
Joint Authors
Morales González, José A.
Madrigal-Santillán, Eduardo
Garcia-Melo, Fernando
Vásquez-Garzón, Verónica R.
Villa-Treviño, Saúl
Mendoza-Pérez, Jorge A.
Alvarez-González, Isela
Madrigal-Bujaidar, Eduardo
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-09-02
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Blueberry is a plant with a number of nutritional and biomedical capabilities.
In the present study we initially evaluated the capacity of its juice (BJ) to inhibit the number of aberrant crypts (AC) induced with azoxymethane (AOM) in mouse.
BJ was administered daily by the oral route to three groups of animals during four weeks (1.6, 4.1, and 15.0 μL/g), respectively, while AOM (10 mg/kg) was intraperitoneally injected to the mentioned groups, twice a week, in weeks two and three of the assay.
We also included two control groups of mice, one administered distilled water and the other the high dose of BJ.
A significant increase of AC was observed in the AOM treated animals, and a mean protection of 75.6% was determined with the two low doses of BJ tested; however, the high dose of the juice administered together with AOM increased the number of crypts more than four times the value observed in animals administered only AOM.
Furthermore, we determined the antioxidant potential of BJ with an ex vivo DPPH assay and found a dose-dependent decrease with a mean of 19.5%.
We also determined the DNA oxidation/antioxidation by identifying 8-hydroxy-2′-deoxyguanosine adducts and found a mean decrease of 44.3% with the BJ administration with respect to the level induced by AOM.
Our results show a complex differential effect of BJ related to the tested doses, opening the need to further evaluate a number of factors so as to determine the possibility of a cocarcinogenic potential.
American Psychological Association (APA)
Alvarez-González, Isela& Garcia-Melo, Fernando& Vásquez-Garzón, Verónica R.& Villa-Treviño, Saúl& Madrigal-Santillán, Eduardo& Morales González, José A.…[et al.]. 2014. Evaluation of Blueberry Juice in Mouse Azoxymethane-Induced Aberrant Crypts and Oxidative Damage. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1035176
Modern Language Association (MLA)
Alvarez-González, Isela…[et al.]. Evaluation of Blueberry Juice in Mouse Azoxymethane-Induced Aberrant Crypts and Oxidative Damage. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-1035176
American Medical Association (AMA)
Alvarez-González, Isela& Garcia-Melo, Fernando& Vásquez-Garzón, Verónica R.& Villa-Treviño, Saúl& Madrigal-Santillán, Eduardo& Morales González, José A.…[et al.]. Evaluation of Blueberry Juice in Mouse Azoxymethane-Induced Aberrant Crypts and Oxidative Damage. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1035176
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1035176