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Isolation, Characterization, Crystal Structure Elucidation, and Anticancer Study of Dimethyl Cardamonin, Isolated from Syzygium campanulatum Korth
المؤلفون المشاركون
Al-Suede, Fouad Saleih R.
Memon, Abdul Hakeem
Ismail, Zhari
Aisha, Abdalrahim F. A.
Hamil, Mohammad Shahrul Ridzuan
Hashim, Suzana
Saeed, Mohammed Ali Ahmed
Laghari, Madeeha
Abdul Majid, Amin Malik Shah
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-10-28
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Syzygium campanulatum Korth is an equatorial, evergreen, aboriginal shrub of Malaysia.
Conventionally it has been used as a stomachic.
However, in the currently conducted study dimethyl cardamonin or 2′,4′-dihydroxy-6′-methoxy-3′,5′-dimethylchalcone (DMC) was isolated from S.
campanulatum Korth, leaf extract.
The structural characterization of DMC was carried out by making use of various techniques including UV, IR, NMR spectral followed by LC-MS, and X-ray crystallographic techniques.
For determining the purity of compound, highly effective techniques including TLC, HPLC, and melting point were used.
The cytotoxicity of DMC and three different extracts of S.
campanulatum was evaluated against human colon cancer cell line (HT-29) by three different assays.
DMC and ethanolic extract revealed potent and dose-dependent cytotoxic activity on the cancer cell line with IC50 12.6 and 90.1 µg/mL, respectively.
Quite astonishingly to our knowledge, this is the very first report on S.
campanulatum as being a rich source (3.5%) of DMC, X-ray crystallography, and anticancer activity on human colon cancer cells.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Memon, Abdul Hakeem& Ismail, Zhari& Aisha, Abdalrahim F. A.& Al-Suede, Fouad Saleih R.& Hamil, Mohammad Shahrul Ridzuan& Hashim, Suzana…[et al.]. 2014. Isolation, Characterization, Crystal Structure Elucidation, and Anticancer Study of Dimethyl Cardamonin, Isolated from Syzygium campanulatum Korth. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1035210
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Memon, Abdul Hakeem…[et al.]. Isolation, Characterization, Crystal Structure Elucidation, and Anticancer Study of Dimethyl Cardamonin, Isolated from Syzygium campanulatum Korth. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-1035210
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Memon, Abdul Hakeem& Ismail, Zhari& Aisha, Abdalrahim F. A.& Al-Suede, Fouad Saleih R.& Hamil, Mohammad Shahrul Ridzuan& Hashim, Suzana…[et al.]. Isolation, Characterization, Crystal Structure Elucidation, and Anticancer Study of Dimethyl Cardamonin, Isolated from Syzygium campanulatum Korth. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1035210
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1035210
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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