Isolation, Characterization, Crystal Structure Elucidation, and Anticancer Study of Dimethyl Cardamonin, Isolated from Syzygium campanulatum Korth
Joint Authors
Al-Suede, Fouad Saleih R.
Memon, Abdul Hakeem
Ismail, Zhari
Aisha, Abdalrahim F. A.
Hamil, Mohammad Shahrul Ridzuan
Hashim, Suzana
Saeed, Mohammed Ali Ahmed
Laghari, Madeeha
Abdul Majid, Amin Malik Shah
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-10-28
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Syzygium campanulatum Korth is an equatorial, evergreen, aboriginal shrub of Malaysia.
Conventionally it has been used as a stomachic.
However, in the currently conducted study dimethyl cardamonin or 2′,4′-dihydroxy-6′-methoxy-3′,5′-dimethylchalcone (DMC) was isolated from S.
campanulatum Korth, leaf extract.
The structural characterization of DMC was carried out by making use of various techniques including UV, IR, NMR spectral followed by LC-MS, and X-ray crystallographic techniques.
For determining the purity of compound, highly effective techniques including TLC, HPLC, and melting point were used.
The cytotoxicity of DMC and three different extracts of S.
campanulatum was evaluated against human colon cancer cell line (HT-29) by three different assays.
DMC and ethanolic extract revealed potent and dose-dependent cytotoxic activity on the cancer cell line with IC50 12.6 and 90.1 µg/mL, respectively.
Quite astonishingly to our knowledge, this is the very first report on S.
campanulatum as being a rich source (3.5%) of DMC, X-ray crystallography, and anticancer activity on human colon cancer cells.
American Psychological Association (APA)
Memon, Abdul Hakeem& Ismail, Zhari& Aisha, Abdalrahim F. A.& Al-Suede, Fouad Saleih R.& Hamil, Mohammad Shahrul Ridzuan& Hashim, Suzana…[et al.]. 2014. Isolation, Characterization, Crystal Structure Elucidation, and Anticancer Study of Dimethyl Cardamonin, Isolated from Syzygium campanulatum Korth. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1035210
Modern Language Association (MLA)
Memon, Abdul Hakeem…[et al.]. Isolation, Characterization, Crystal Structure Elucidation, and Anticancer Study of Dimethyl Cardamonin, Isolated from Syzygium campanulatum Korth. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-1035210
American Medical Association (AMA)
Memon, Abdul Hakeem& Ismail, Zhari& Aisha, Abdalrahim F. A.& Al-Suede, Fouad Saleih R.& Hamil, Mohammad Shahrul Ridzuan& Hashim, Suzana…[et al.]. Isolation, Characterization, Crystal Structure Elucidation, and Anticancer Study of Dimethyl Cardamonin, Isolated from Syzygium campanulatum Korth. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1035210
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1035210