Intestinal Transportations of Main Chemical Compositions of Polygoni Multiflori Radix in Caco-2 Cell Model
المؤلفون المشاركون
Li, Na
Zhao, Ronghua
Yu, Jie
Lin, Pei
Li, Yunfei
Mao, Xiaojian
Bao, Getuzhaori
Gu, Wen
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-02-12
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Context.
Polygoni Multiflori Radix (PMR) is originated from the root of Polygonum multiflorum Thunb.
and used in oriental countries for centuries.
However, little researches pay close attention to the absorption of its major constituents.
Objective.
Transepithelial transport of TSG, RL, PL, and four anthraquinones is carried out.
Materials and Methods.
Caco-2 cell monolayer, which represented a well-established model for the study of intestinal transport of nutrients and xenobiotics, was used in this paper.
Results.
The apparent permeability coefficients ( P app ) in the Caco-2 cell monolayers were TSG (2.372 × 10−9) < EG (2.391 × 10−9) < EN (2.483 × 10−9) < PL (4.917 × 10−9) < RN (1.707 × 10−8) < RL (1.778 × 10−8) < AE (1.952 × 10−8).
Thus, RN, RL, and AE were considered partly absorbed, while other constituents were hardly absorbed.
Discussion and Conclusion.
Glycosides showed poor permeabilities than aglycones.
In the meantime, TSG and EN gave out poor recovery rates in this assay, which indicated that TSG and EN may accumulate or metabolise in the Caco-2 cells.
In silico prediction indicated that Gibbs energy ( r = 0.751 , p < 0 .
05 ) and heat of form ( r = 0.701 , p < 0 .
05 ) were strongly positively correlated with P app .
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Yu, Jie& Li, Na& Lin, Pei& Li, Yunfei& Mao, Xiaojian& Bao, Getuzhaori…[et al.]. 2014. Intestinal Transportations of Main Chemical Compositions of Polygoni Multiflori Radix in Caco-2 Cell Model. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1035221
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Yu, Jie…[et al.]. Intestinal Transportations of Main Chemical Compositions of Polygoni Multiflori Radix in Caco-2 Cell Model. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-1035221
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Yu, Jie& Li, Na& Lin, Pei& Li, Yunfei& Mao, Xiaojian& Bao, Getuzhaori…[et al.]. Intestinal Transportations of Main Chemical Compositions of Polygoni Multiflori Radix in Caco-2 Cell Model. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1035221
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1035221
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر