Intestinal Transportations of Main Chemical Compositions of Polygoni Multiflori Radix in Caco-2 Cell Model
Joint Authors
Li, Na
Zhao, Ronghua
Yu, Jie
Lin, Pei
Li, Yunfei
Mao, Xiaojian
Bao, Getuzhaori
Gu, Wen
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-02-12
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Context.
Polygoni Multiflori Radix (PMR) is originated from the root of Polygonum multiflorum Thunb.
and used in oriental countries for centuries.
However, little researches pay close attention to the absorption of its major constituents.
Objective.
Transepithelial transport of TSG, RL, PL, and four anthraquinones is carried out.
Materials and Methods.
Caco-2 cell monolayer, which represented a well-established model for the study of intestinal transport of nutrients and xenobiotics, was used in this paper.
Results.
The apparent permeability coefficients ( P app ) in the Caco-2 cell monolayers were TSG (2.372 × 10−9) < EG (2.391 × 10−9) < EN (2.483 × 10−9) < PL (4.917 × 10−9) < RN (1.707 × 10−8) < RL (1.778 × 10−8) < AE (1.952 × 10−8).
Thus, RN, RL, and AE were considered partly absorbed, while other constituents were hardly absorbed.
Discussion and Conclusion.
Glycosides showed poor permeabilities than aglycones.
In the meantime, TSG and EN gave out poor recovery rates in this assay, which indicated that TSG and EN may accumulate or metabolise in the Caco-2 cells.
In silico prediction indicated that Gibbs energy ( r = 0.751 , p < 0 .
05 ) and heat of form ( r = 0.701 , p < 0 .
05 ) were strongly positively correlated with P app .
American Psychological Association (APA)
Yu, Jie& Li, Na& Lin, Pei& Li, Yunfei& Mao, Xiaojian& Bao, Getuzhaori…[et al.]. 2014. Intestinal Transportations of Main Chemical Compositions of Polygoni Multiflori Radix in Caco-2 Cell Model. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1035221
Modern Language Association (MLA)
Yu, Jie…[et al.]. Intestinal Transportations of Main Chemical Compositions of Polygoni Multiflori Radix in Caco-2 Cell Model. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-1035221
American Medical Association (AMA)
Yu, Jie& Li, Na& Lin, Pei& Li, Yunfei& Mao, Xiaojian& Bao, Getuzhaori…[et al.]. Intestinal Transportations of Main Chemical Compositions of Polygoni Multiflori Radix in Caco-2 Cell Model. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1035221
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1035221