Effect of Wasabi Component 6-(Methylsulfinyl)hexyl Isothiocyanate and Derivatives on Human Pancreatic Cancer Cells
المؤلفون المشاركون
Liao, Hui-Fen
Huang, Yu-Chuen
Chen, Yu-Jen
Tsai, Tung-Hu
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-01-20
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
The naturally occurring compound 6-(methylsulfinyl)hexyl isothiocyanate (6-MITC) was isolated from Wasabia japonica (Wasabi), a pungent spice used in Japanese food worldwide.
The synthetic derivatives 6-(methylsulfenyl)hexyl isothiocyanate (I7447) and 6-(methylsulfonyl)hexyl isothiocyanate (I7557) are small molecule compounds derived from 6-MITC.
This study aimed to evaluate the effect of these compounds on human pancreatic cancer cells.
Human pancreatic cancer cell lines PANC-1 and BxPC-3 were used to perform an MTT assay for cell viability and Liu’s stain for morphological observation.
The cell cycle was analyzed by DNA histogram.
Aldehyde dehydrogenase (ALDH) activity was used as a marker for cancer stem cells (CSC).
Western blotting was performed for the expression of proteins related to CSC signaling.
The results showed that compounds 6-MITC and I7557, but not I7447, inhibited viability of both PANC-1 and BxPC-3 cells.
Morphological observation showed mitotic arrest and apoptosis in 6-MITC- and I7557-treated cells.
These two compounds induced G2/M phase arrest and hypoploid population.
Percentages of ALDH-positive PANC-1 cells were markedly reduced by 6-MITC and I7557 treatment.
The expression of CSC signaling molecule SOX2, but not NOTCH1, ABCG2, Sonic hedgehog, or OCT4, was inhibited by 6-MITC and I7557.
In conclusion, wasabi compounds 6-MITC and I7557 may possess activity against the growth and CSC phenotypes of human pancreatic cancer cells.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Chen, Yu-Jen& Huang, Yu-Chuen& Tsai, Tung-Hu& Liao, Hui-Fen. 2014. Effect of Wasabi Component 6-(Methylsulfinyl)hexyl Isothiocyanate and Derivatives on Human Pancreatic Cancer Cells. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1035225
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Chen, Yu-Jen…[et al.]. Effect of Wasabi Component 6-(Methylsulfinyl)hexyl Isothiocyanate and Derivatives on Human Pancreatic Cancer Cells. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-1035225
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Chen, Yu-Jen& Huang, Yu-Chuen& Tsai, Tung-Hu& Liao, Hui-Fen. Effect of Wasabi Component 6-(Methylsulfinyl)hexyl Isothiocyanate and Derivatives on Human Pancreatic Cancer Cells. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1035225
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1035225
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر