Effects of Chinese Formula Jueyin Granules on Psoriasis in an Animal Model

المؤلفون المشاركون

Li, Fu-Lun
Xu, Rong
Li, Xin
Ma, Tian
Jiang, Wen-cheng
Chen, Jie
Wu, Tie-jun
Nian, Hua
Huang, Qian-yuan
Xiao, Qing-qing
Jian, Qiang
Li, Bin

المصدر

Evidence-Based Complementary and Alternative Medicine

العدد

المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-8، 8ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2014-08-03

دولة النشر

مصر

عدد الصفحات

8

التخصصات الرئيسية

الطب البشري

الملخص EN

Although Traditional Chinese medicine (TCM) is known to be effective for psoriasis patients, the responsible mechanisms still remain poorly understood.

In this study, we aimed to evaluate the effect of one formula, named Jueyin granules (JYG) in the mouse model of the vaginal epithelium and tail epidermis.

Additionally, we also determined the anti-inflammatory effects of JYG in an imiquimod- (IMQ-) induced psoriasis-like skin mouse model.

Our results show that JYG can attenuate the IMQ-induced psoriasis-like inflammation, accompanied with increased epidermal hyperplasia.

We also measured estrogenic stage mitosis of vaginal epithelial cells and the formation of granular cell layers in male mouse tails per 100 scales, as well as the tissue nitric oxide (NO) and malondialdehyde (MDA) levels using the ELISA method.

The results suggest that JYG significantly inhibited mitosis in mouse vaginal epithelial cells, promoted the formation of the squamous epidermal granular layer in mice tails, and reduced the levels of NO and MDA in an imiquimod-induced psoriasis-like skin mouse model after 14 d (P<0.05).

These results demonstrate that JYG might be an effective clinical treatment for psoriasis and the effects may be related to inhibited keratinocytes proliferation, improved parakeratotic epidermal cells, and reduced expression of NO and MDA.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Ma, Tian& Jiang, Wen-cheng& Li, Xin& Chen, Jie& Wu, Tie-jun& Nian, Hua…[et al.]. 2014. Effects of Chinese Formula Jueyin Granules on Psoriasis in an Animal Model. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1035251

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Ma, Tian…[et al.]. Effects of Chinese Formula Jueyin Granules on Psoriasis in an Animal Model. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-1035251

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Ma, Tian& Jiang, Wen-cheng& Li, Xin& Chen, Jie& Wu, Tie-jun& Nian, Hua…[et al.]. Effects of Chinese Formula Jueyin Granules on Psoriasis in an Animal Model. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1035251

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1035251