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Effects of Chinese Formula Jueyin Granules on Psoriasis in an Animal Model
Joint Authors
Li, Fu-Lun
Xu, Rong
Li, Xin
Ma, Tian
Jiang, Wen-cheng
Chen, Jie
Wu, Tie-jun
Nian, Hua
Huang, Qian-yuan
Xiao, Qing-qing
Jian, Qiang
Li, Bin
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-08-03
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Although Traditional Chinese medicine (TCM) is known to be effective for psoriasis patients, the responsible mechanisms still remain poorly understood.
In this study, we aimed to evaluate the effect of one formula, named Jueyin granules (JYG) in the mouse model of the vaginal epithelium and tail epidermis.
Additionally, we also determined the anti-inflammatory effects of JYG in an imiquimod- (IMQ-) induced psoriasis-like skin mouse model.
Our results show that JYG can attenuate the IMQ-induced psoriasis-like inflammation, accompanied with increased epidermal hyperplasia.
We also measured estrogenic stage mitosis of vaginal epithelial cells and the formation of granular cell layers in male mouse tails per 100 scales, as well as the tissue nitric oxide (NO) and malondialdehyde (MDA) levels using the ELISA method.
The results suggest that JYG significantly inhibited mitosis in mouse vaginal epithelial cells, promoted the formation of the squamous epidermal granular layer in mice tails, and reduced the levels of NO and MDA in an imiquimod-induced psoriasis-like skin mouse model after 14 d (P<0.05).
These results demonstrate that JYG might be an effective clinical treatment for psoriasis and the effects may be related to inhibited keratinocytes proliferation, improved parakeratotic epidermal cells, and reduced expression of NO and MDA.
American Psychological Association (APA)
Ma, Tian& Jiang, Wen-cheng& Li, Xin& Chen, Jie& Wu, Tie-jun& Nian, Hua…[et al.]. 2014. Effects of Chinese Formula Jueyin Granules on Psoriasis in an Animal Model. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1035251
Modern Language Association (MLA)
Ma, Tian…[et al.]. Effects of Chinese Formula Jueyin Granules on Psoriasis in an Animal Model. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-1035251
American Medical Association (AMA)
Ma, Tian& Jiang, Wen-cheng& Li, Xin& Chen, Jie& Wu, Tie-jun& Nian, Hua…[et al.]. Effects of Chinese Formula Jueyin Granules on Psoriasis in an Animal Model. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1035251
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1035251