Treatment of Acute Lymphoblastic Leukemia from Traditional Chinese Medicine
المؤلفون المشاركون
Chen, Calvin Yu-Chian
Hsiao, Ya-Li
Chang, Pei-Chun
Kuo, Chia-Chen
Huang, Hung-Jin
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-21، 21ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-05-22
دولة النشر
مصر
عدد الصفحات
21
التخصصات الرئيسية
الملخص EN
Acute lymphoblastic leukemia (ALL) is a cancer that immature white blood cells continuously overproduce in the bone marrow.
These cells crowd out normal cells in the bone marrow bringing damage and death.
Methotrexate (MTX) is a drug used in the treatment of various cancer and autoimmune diseases.
In particular, for the treatment of childhood acute lymphoblastic leukemia, it had significant effect.
MTX competitively inhibits dihydrofolate reductase (DHFR), an enzyme that participates in the tetrahydrofolate synthesis so as to inhibit purine synthesis.
In addition, its downstream metabolite methotrexate polyglutamates (MTX-PGs) inhibit the thymidylate synthase (TS).
Therefore, MTX can inhibit the synthesis of DNA.
However, MTX has cytotoxicity and neurotoxin may cause multiple organ injury and is potentially lethal.
Thus, the lower toxicity drugs are necessary to be developed.
Recently, diseases treatments with Traditional Chinese Medicine (TCM) as complements are getting more and more attention.
In this study, we attempted to discover the compounds with drug-like potential for ALL treatment from the components in TCM.
We applied virtual screen and QSAR models based on structure-based and ligand-based studies to identify the potential TCM component compounds.
Our results show that the TCM compounds adenosine triphosphate, manninotriose, raffinose, and stachyose could have potential to improve the side effects of MTX for ALL treatment.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Hsiao, Ya-Li& Chang, Pei-Chun& Huang, Hung-Jin& Kuo, Chia-Chen& Chen, Calvin Yu-Chian. 2014. Treatment of Acute Lymphoblastic Leukemia from Traditional Chinese Medicine. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-21.
https://search.emarefa.net/detail/BIM-1035295
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Hsiao, Ya-Li…[et al.]. Treatment of Acute Lymphoblastic Leukemia from Traditional Chinese Medicine. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-21.
https://search.emarefa.net/detail/BIM-1035295
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Hsiao, Ya-Li& Chang, Pei-Chun& Huang, Hung-Jin& Kuo, Chia-Chen& Chen, Calvin Yu-Chian. Treatment of Acute Lymphoblastic Leukemia from Traditional Chinese Medicine. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-21.
https://search.emarefa.net/detail/BIM-1035295
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1035295
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر