Treatment of Acute Lymphoblastic Leukemia from Traditional Chinese Medicine
Joint Authors
Chen, Calvin Yu-Chian
Hsiao, Ya-Li
Chang, Pei-Chun
Kuo, Chia-Chen
Huang, Hung-Jin
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-21, 21 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-22
Country of Publication
Egypt
No. of Pages
21
Main Subjects
Abstract EN
Acute lymphoblastic leukemia (ALL) is a cancer that immature white blood cells continuously overproduce in the bone marrow.
These cells crowd out normal cells in the bone marrow bringing damage and death.
Methotrexate (MTX) is a drug used in the treatment of various cancer and autoimmune diseases.
In particular, for the treatment of childhood acute lymphoblastic leukemia, it had significant effect.
MTX competitively inhibits dihydrofolate reductase (DHFR), an enzyme that participates in the tetrahydrofolate synthesis so as to inhibit purine synthesis.
In addition, its downstream metabolite methotrexate polyglutamates (MTX-PGs) inhibit the thymidylate synthase (TS).
Therefore, MTX can inhibit the synthesis of DNA.
However, MTX has cytotoxicity and neurotoxin may cause multiple organ injury and is potentially lethal.
Thus, the lower toxicity drugs are necessary to be developed.
Recently, diseases treatments with Traditional Chinese Medicine (TCM) as complements are getting more and more attention.
In this study, we attempted to discover the compounds with drug-like potential for ALL treatment from the components in TCM.
We applied virtual screen and QSAR models based on structure-based and ligand-based studies to identify the potential TCM component compounds.
Our results show that the TCM compounds adenosine triphosphate, manninotriose, raffinose, and stachyose could have potential to improve the side effects of MTX for ALL treatment.
American Psychological Association (APA)
Hsiao, Ya-Li& Chang, Pei-Chun& Huang, Hung-Jin& Kuo, Chia-Chen& Chen, Calvin Yu-Chian. 2014. Treatment of Acute Lymphoblastic Leukemia from Traditional Chinese Medicine. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-21.
https://search.emarefa.net/detail/BIM-1035295
Modern Language Association (MLA)
Hsiao, Ya-Li…[et al.]. Treatment of Acute Lymphoblastic Leukemia from Traditional Chinese Medicine. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-21.
https://search.emarefa.net/detail/BIM-1035295
American Medical Association (AMA)
Hsiao, Ya-Li& Chang, Pei-Chun& Huang, Hung-Jin& Kuo, Chia-Chen& Chen, Calvin Yu-Chian. Treatment of Acute Lymphoblastic Leukemia from Traditional Chinese Medicine. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-21.
https://search.emarefa.net/detail/BIM-1035295
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1035295