Ameliorating Adriamycin-Induced Chronic Kidney Disease in Rats by Orally Administrated Cardiotoxin from Naja naja atra Venom
المؤلفون المشاركون
Kou, Jian-Qun
Qin, Zheng-Hong
Ding, Zhi-Hui
Xu, Li-Min
Xu, Yin-Li
Chen, Cao-Xin
Yu, Hong-Pei
Xie, Yan
Wang, Shu-Zhi
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-04-30
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Previous studies reported the oral administration of Naja naja atra venom (NNAV) reduced adriamycin-induced chronic kidney damage.
This study investigated the effects of intragastric administrated cardiotoxin from Naja naja atra venom on chronic kidney disease in rats.
Wistar rats were injected with adriamycin (ADR; 6 mg/kg body weight) via the tail vein to induce chronic kidney disease.
The cardiotoxin was administrated daily by intragastric injection at doses of 45, 90, and 180 μg/kg body weight until the end of the protocol.
The rats were placed in metabolic cages for 24 hours to collect urine, for determination of proteinuria, once a week.
After 6 weeks, the rats were sacrificed to determine serum profiles relevant to chronic kidney disease, including albumin, total cholesterol, phosphorus, blood urea nitrogen, and serum creatinine.
Kidney histology was examined with hematoxylin and eosin, periodic acid-Schiff, and Masson’s trichrome staining.
The levels of kidney podocin were analyzed by Western blot analysis and immunofluorescence.
We found that cardiotoxin reduced proteinuria and can improve biological parameters in the adriamycin-induced kidney disease model.
Cardiotoxin also reduced adriamycin-induced kidney pathology, suggesting that cardiotoxin is an active component of NNAV for ameliorating adriamycin-induced kidney damage and may have a potential therapeutic value on chronic kidney disease.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ding, Zhi-Hui& Xu, Li-Min& Wang, Shu-Zhi& Kou, Jian-Qun& Xu, Yin-Li& Chen, Cao-Xin…[et al.]. 2014. Ameliorating Adriamycin-Induced Chronic Kidney Disease in Rats by Orally Administrated Cardiotoxin from Naja naja atra Venom. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1035308
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ding, Zhi-Hui…[et al.]. Ameliorating Adriamycin-Induced Chronic Kidney Disease in Rats by Orally Administrated Cardiotoxin from Naja naja atra Venom. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-1035308
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ding, Zhi-Hui& Xu, Li-Min& Wang, Shu-Zhi& Kou, Jian-Qun& Xu, Yin-Li& Chen, Cao-Xin…[et al.]. Ameliorating Adriamycin-Induced Chronic Kidney Disease in Rats by Orally Administrated Cardiotoxin from Naja naja atra Venom. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1035308
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1035308
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر