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Ameliorating Adriamycin-Induced Chronic Kidney Disease in Rats by Orally Administrated Cardiotoxin from Naja naja atra Venom
Joint Authors
Kou, Jian-Qun
Qin, Zheng-Hong
Ding, Zhi-Hui
Xu, Li-Min
Xu, Yin-Li
Chen, Cao-Xin
Yu, Hong-Pei
Xie, Yan
Wang, Shu-Zhi
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-30
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Previous studies reported the oral administration of Naja naja atra venom (NNAV) reduced adriamycin-induced chronic kidney damage.
This study investigated the effects of intragastric administrated cardiotoxin from Naja naja atra venom on chronic kidney disease in rats.
Wistar rats were injected with adriamycin (ADR; 6 mg/kg body weight) via the tail vein to induce chronic kidney disease.
The cardiotoxin was administrated daily by intragastric injection at doses of 45, 90, and 180 μg/kg body weight until the end of the protocol.
The rats were placed in metabolic cages for 24 hours to collect urine, for determination of proteinuria, once a week.
After 6 weeks, the rats were sacrificed to determine serum profiles relevant to chronic kidney disease, including albumin, total cholesterol, phosphorus, blood urea nitrogen, and serum creatinine.
Kidney histology was examined with hematoxylin and eosin, periodic acid-Schiff, and Masson’s trichrome staining.
The levels of kidney podocin were analyzed by Western blot analysis and immunofluorescence.
We found that cardiotoxin reduced proteinuria and can improve biological parameters in the adriamycin-induced kidney disease model.
Cardiotoxin also reduced adriamycin-induced kidney pathology, suggesting that cardiotoxin is an active component of NNAV for ameliorating adriamycin-induced kidney damage and may have a potential therapeutic value on chronic kidney disease.
American Psychological Association (APA)
Ding, Zhi-Hui& Xu, Li-Min& Wang, Shu-Zhi& Kou, Jian-Qun& Xu, Yin-Li& Chen, Cao-Xin…[et al.]. 2014. Ameliorating Adriamycin-Induced Chronic Kidney Disease in Rats by Orally Administrated Cardiotoxin from Naja naja atra Venom. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1035308
Modern Language Association (MLA)
Ding, Zhi-Hui…[et al.]. Ameliorating Adriamycin-Induced Chronic Kidney Disease in Rats by Orally Administrated Cardiotoxin from Naja naja atra Venom. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-1035308
American Medical Association (AMA)
Ding, Zhi-Hui& Xu, Li-Min& Wang, Shu-Zhi& Kou, Jian-Qun& Xu, Yin-Li& Chen, Cao-Xin…[et al.]. Ameliorating Adriamycin-Induced Chronic Kidney Disease in Rats by Orally Administrated Cardiotoxin from Naja naja atra Venom. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1035308
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1035308