Effect of Garden Cress Seeds Powder and Its Alcoholic Extract on the Metabolic Activity of CYP2D6 and CYP3A4
المؤلفون المشاركون
Alkharfy, Khalid M.
Al-Jenoobi, F. I.
Al-Suwayeh, S. A.
Alam, Mohd Aftab
Al-Mohizea, Abdullah M.
Al-Thukair, Areej A.
Abbas, Fawkeya A.
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-03-10
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
The powder and alcoholic extract of dried seeds of garden cress were investigated for their effect on metabolic activity of CYP2D6 and CYP3A4 enzymes.
In vitro and clinical studies were conducted on human liver microsomes and healthy human subjects, respectively.
Dextromethorphan was used as a common marker for measuring metabolic activity of CYP2D6 and CYP3A4 enzymes.
In in vitro studies, microsomes were incubated with NADPH in presence and absence of different concentrations of seeds extract.
Clinical investigations were performed in two phases.
In phase I, six healthy female volunteers were administered a single dose of dextromethorphan and in phase II volunteers were treated with seeds powder for seven days and dextromethorphan was administered with last dose.
The O-demethylated and N-demethylated metabolites of dextromethorphan were measured as dextrorphan (DOR) and 3-methoxymorphinan (3-MM), respectively.
Observations suggested that garden cress inhibits the formation of DOR and 3-MM metabolites.
This inhibition of metabolite level was attributed to the inhibition of CYP2D6 and CYP3A4 activity.
Garden cress decreases the level of DOR and 3-MM in urine and significantly increases the urinary metabolic ratio of DEX/DOR and DEX/3-MM.
The findings suggested that garden cress seeds powder and ethanolic extract have the potential to interact with CYP2D6 and CYP3A4 substrates.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Al-Jenoobi, F. I.& Al-Thukair, Areej A.& Alam, Mohd Aftab& Abbas, Fawkeya A.& Al-Mohizea, Abdullah M.& Alkharfy, Khalid M.…[et al.]. 2014. Effect of Garden Cress Seeds Powder and Its Alcoholic Extract on the Metabolic Activity of CYP2D6 and CYP3A4. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1035313
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Al-Jenoobi, F. I.…[et al.]. Effect of Garden Cress Seeds Powder and Its Alcoholic Extract on the Metabolic Activity of CYP2D6 and CYP3A4. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-1035313
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Al-Jenoobi, F. I.& Al-Thukair, Areej A.& Alam, Mohd Aftab& Abbas, Fawkeya A.& Al-Mohizea, Abdullah M.& Alkharfy, Khalid M.…[et al.]. Effect of Garden Cress Seeds Powder and Its Alcoholic Extract on the Metabolic Activity of CYP2D6 and CYP3A4. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1035313
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1035313
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر