Lingonberry (Vaccinium vitis-idaea L.) Exhibits Antidiabetic Activities in a Mouse Model of Diet-Induced Obesity
المؤلفون المشاركون
Musallam, Lina
Ouchfoun, Meriem
Arnason, John
Haddad, Pierre S.
Brault, Antoine
Vallerand, Diane
Eid, Hoda M.
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-06-10
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Vaccinium vitis-idaea, commonly known as lingonberry, has been identified among species used by the Cree of Eeyou Istchee of northern Quebec to treat symptoms of diabetes.
In a previous study, the ethanol extract of berries of V.
vitis-idaea enhanced glucose uptake in C2C12 muscle cells via stimulation of AMP-activated protein kinase (AMPK) pathway.
The purpose of this study was to examine the effect of plant extract in a dietary mouse model of mild type 2 diabetes.
C57BL/6 mice fed a high-fat diet (HFD, ∼35% lipids) for 8 weeks that become obese and insulin-resistant (diet-induced obesity, DIO) were used.
Treatment began by adding V.
vitis-idaea extract to HFD at 3 different concentrations (125, 250, and 500 mg/Kg) for a subsequent period of 8 weeks (total HFD, 16 weeks).
The plant extract significantly decreased glycemia and strongly tended to decrease insulin levels in this model.
This was correlated with a significant increase in GLUT4 content and activation of the AMPK and Akt pathways in skeletal muscle.
V.
vitis-idaea treatment also improved hepatic steatosis by decreasing hepatic triglyceride levels and significantly activated liver AMPK and Akt pathways.
The results of the present study confirm that V.
vitis-idaea represents a culturally relevant treatment option for Cree diabetics and pave the way to clinical studies.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Eid, Hoda M.& Ouchfoun, Meriem& Brault, Antoine& Vallerand, Diane& Musallam, Lina& Arnason, John…[et al.]. 2014. Lingonberry (Vaccinium vitis-idaea L.) Exhibits Antidiabetic Activities in a Mouse Model of Diet-Induced Obesity. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1035320
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Eid, Hoda M.…[et al.]. Lingonberry (Vaccinium vitis-idaea L.) Exhibits Antidiabetic Activities in a Mouse Model of Diet-Induced Obesity. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-1035320
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Eid, Hoda M.& Ouchfoun, Meriem& Brault, Antoine& Vallerand, Diane& Musallam, Lina& Arnason, John…[et al.]. Lingonberry (Vaccinium vitis-idaea L.) Exhibits Antidiabetic Activities in a Mouse Model of Diet-Induced Obesity. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1035320
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1035320
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر