Lingonberry (Vaccinium vitis-idaea L.)‎ Exhibits Antidiabetic Activities in a Mouse Model of Diet-Induced Obesity

Abstract EN

Vaccinium vitis-idaea, commonly known as lingonberry, has been identified among species used by the Cree of Eeyou Istchee of northern Quebec to treat symptoms of diabetes.

In a previous study, the ethanol extract of berries of V.

vitis-idaea enhanced glucose uptake in C2C12 muscle cells via stimulation of AMP-activated protein kinase (AMPK) pathway.

The purpose of this study was to examine the effect of plant extract in a dietary mouse model of mild type 2 diabetes.

C57BL/6 mice fed a high-fat diet (HFD, ∼35% lipids) for 8 weeks that become obese and insulin-resistant (diet-induced obesity, DIO) were used.

Treatment began by adding V.

vitis-idaea extract to HFD at 3 different concentrations (125, 250, and 500 mg/Kg) for a subsequent period of 8 weeks (total HFD, 16 weeks).

The plant extract significantly decreased glycemia and strongly tended to decrease insulin levels in this model.

This was correlated with a significant increase in GLUT4 content and activation of the AMPK and Akt pathways in skeletal muscle.

V.

vitis-idaea treatment also improved hepatic steatosis by decreasing hepatic triglyceride levels and significantly activated liver AMPK and Akt pathways.

The results of the present study confirm that V.

vitis-idaea represents a culturally relevant treatment option for Cree diabetics and pave the way to clinical studies.