![](/images/graphics-bg.png)
Lingonberry (Vaccinium vitis-idaea L.) Exhibits Antidiabetic Activities in a Mouse Model of Diet-Induced Obesity
Joint Authors
Musallam, Lina
Ouchfoun, Meriem
Arnason, John
Haddad, Pierre S.
Brault, Antoine
Vallerand, Diane
Eid, Hoda M.
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-10
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Vaccinium vitis-idaea, commonly known as lingonberry, has been identified among species used by the Cree of Eeyou Istchee of northern Quebec to treat symptoms of diabetes.
In a previous study, the ethanol extract of berries of V.
vitis-idaea enhanced glucose uptake in C2C12 muscle cells via stimulation of AMP-activated protein kinase (AMPK) pathway.
The purpose of this study was to examine the effect of plant extract in a dietary mouse model of mild type 2 diabetes.
C57BL/6 mice fed a high-fat diet (HFD, ∼35% lipids) for 8 weeks that become obese and insulin-resistant (diet-induced obesity, DIO) were used.
Treatment began by adding V.
vitis-idaea extract to HFD at 3 different concentrations (125, 250, and 500 mg/Kg) for a subsequent period of 8 weeks (total HFD, 16 weeks).
The plant extract significantly decreased glycemia and strongly tended to decrease insulin levels in this model.
This was correlated with a significant increase in GLUT4 content and activation of the AMPK and Akt pathways in skeletal muscle.
V.
vitis-idaea treatment also improved hepatic steatosis by decreasing hepatic triglyceride levels and significantly activated liver AMPK and Akt pathways.
The results of the present study confirm that V.
vitis-idaea represents a culturally relevant treatment option for Cree diabetics and pave the way to clinical studies.
American Psychological Association (APA)
Eid, Hoda M.& Ouchfoun, Meriem& Brault, Antoine& Vallerand, Diane& Musallam, Lina& Arnason, John…[et al.]. 2014. Lingonberry (Vaccinium vitis-idaea L.) Exhibits Antidiabetic Activities in a Mouse Model of Diet-Induced Obesity. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1035320
Modern Language Association (MLA)
Eid, Hoda M.…[et al.]. Lingonberry (Vaccinium vitis-idaea L.) Exhibits Antidiabetic Activities in a Mouse Model of Diet-Induced Obesity. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-1035320
American Medical Association (AMA)
Eid, Hoda M.& Ouchfoun, Meriem& Brault, Antoine& Vallerand, Diane& Musallam, Lina& Arnason, John…[et al.]. Lingonberry (Vaccinium vitis-idaea L.) Exhibits Antidiabetic Activities in a Mouse Model of Diet-Induced Obesity. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1035320
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1035320