Comparison of Electroacupuncture and Morphine-Mediated Analgesic Patterns in a Plantar Incision-Induced Pain Model
المؤلفون المشاركون
Chen, Kuen-Bao
Zeng, Yen-Jing
Tsai, Shih-Ying
Hsu, Sheng-Feng
Chen, Julia Yi-Ru
Wen, Yeong-Ray
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-11-02
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Electroacupuncture (EA) is a complementary therapy to improve morphine analgesia for postoperative pain, but underlying mechanism is not well-known.
Herein, we investigated EA-induced analgesic effect in a plantar incision (PI) model in male Sprague-Dawley rats.
PI was performed at the left hind paw.
EA of 4 Hz and high intensity or sham needling was conducted at right ST36 prior to PI and repeated for another 2 days.
Behavioral responses to mechanical and thermal stimuli, spinal phospho-ERK, and Fos expression were all analyzed.
In additional groups, naloxone and morphine were administered to elucidate involvement of opioid receptors and for comparison with EA.
EA pretreatment significantly reduced post-PI tactile allodynia for over 1 day; repeated treatments maintained analgesic effect.
Intraperitoneal naloxone could reverse EA analgesia.
Low-dose subcutaneous morphine (1 mg/kg) had stronger inhibitory effect on PI-induced allodynia than EA for 1 h.
However, analgesic tolerance appeared after repeated morphine injections.
Both EA and morphine could equally inhibit PI-induced p-ERK and Fos inductions.
We conclude that though EA and morphine attenuate postincision pain through opioid receptor activations, daily EA treatments result in analgesic accumulation whereas daily morphine injections develop analgesic tolerance.
Discrepant pathways and mechanisms underlying two analgesic means may account for the results.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zeng, Yen-Jing& Tsai, Shih-Ying& Chen, Kuen-Bao& Hsu, Sheng-Feng& Chen, Julia Yi-Ru& Wen, Yeong-Ray. 2014. Comparison of Electroacupuncture and Morphine-Mediated Analgesic Patterns in a Plantar Incision-Induced Pain Model. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-1035328
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zeng, Yen-Jing…[et al.]. Comparison of Electroacupuncture and Morphine-Mediated Analgesic Patterns in a Plantar Incision-Induced Pain Model. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-12.
https://search.emarefa.net/detail/BIM-1035328
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zeng, Yen-Jing& Tsai, Shih-Ying& Chen, Kuen-Bao& Hsu, Sheng-Feng& Chen, Julia Yi-Ru& Wen, Yeong-Ray. Comparison of Electroacupuncture and Morphine-Mediated Analgesic Patterns in a Plantar Incision-Induced Pain Model. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-1035328
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1035328
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر