Comparison of Electroacupuncture and Morphine-Mediated Analgesic Patterns in a Plantar Incision-Induced Pain Model
Joint Authors
Chen, Kuen-Bao
Zeng, Yen-Jing
Tsai, Shih-Ying
Hsu, Sheng-Feng
Chen, Julia Yi-Ru
Wen, Yeong-Ray
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-11-02
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Electroacupuncture (EA) is a complementary therapy to improve morphine analgesia for postoperative pain, but underlying mechanism is not well-known.
Herein, we investigated EA-induced analgesic effect in a plantar incision (PI) model in male Sprague-Dawley rats.
PI was performed at the left hind paw.
EA of 4 Hz and high intensity or sham needling was conducted at right ST36 prior to PI and repeated for another 2 days.
Behavioral responses to mechanical and thermal stimuli, spinal phospho-ERK, and Fos expression were all analyzed.
In additional groups, naloxone and morphine were administered to elucidate involvement of opioid receptors and for comparison with EA.
EA pretreatment significantly reduced post-PI tactile allodynia for over 1 day; repeated treatments maintained analgesic effect.
Intraperitoneal naloxone could reverse EA analgesia.
Low-dose subcutaneous morphine (1 mg/kg) had stronger inhibitory effect on PI-induced allodynia than EA for 1 h.
However, analgesic tolerance appeared after repeated morphine injections.
Both EA and morphine could equally inhibit PI-induced p-ERK and Fos inductions.
We conclude that though EA and morphine attenuate postincision pain through opioid receptor activations, daily EA treatments result in analgesic accumulation whereas daily morphine injections develop analgesic tolerance.
Discrepant pathways and mechanisms underlying two analgesic means may account for the results.
American Psychological Association (APA)
Zeng, Yen-Jing& Tsai, Shih-Ying& Chen, Kuen-Bao& Hsu, Sheng-Feng& Chen, Julia Yi-Ru& Wen, Yeong-Ray. 2014. Comparison of Electroacupuncture and Morphine-Mediated Analgesic Patterns in a Plantar Incision-Induced Pain Model. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-1035328
Modern Language Association (MLA)
Zeng, Yen-Jing…[et al.]. Comparison of Electroacupuncture and Morphine-Mediated Analgesic Patterns in a Plantar Incision-Induced Pain Model. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-12.
https://search.emarefa.net/detail/BIM-1035328
American Medical Association (AMA)
Zeng, Yen-Jing& Tsai, Shih-Ying& Chen, Kuen-Bao& Hsu, Sheng-Feng& Chen, Julia Yi-Ru& Wen, Yeong-Ray. Comparison of Electroacupuncture and Morphine-Mediated Analgesic Patterns in a Plantar Incision-Induced Pain Model. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-1035328
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1035328