Coadministration of Pinellia ternata Can Significantly Reduce Aconitum carmichaelii to Inhibit CYP3A Activity in Rats
المؤلفون المشاركون
Xu, Ying
Wu, Jinjun
Cheng, Zaixing
Zhu, Lijun
Zhang, Guiyu
Wang, Ying
Liu, Zhong-Qiu
Lin, Na
Lu, Lin-lin
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-10-13
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Chuanwu (CW), the mother root of Aconitum carmichaelii Debx., is a traditional Chinese medicine (TCM) for treating traumatic injuries, rheumatoid arthritis, and tumors.
CW coadministered with banxia (BX), the root of Pinellia ternata, is also widely prescribed in clinical practice.
However, the mechanism of this combination is yet deciphered.
Current study aimed to investigate the effects of CW, including raw chuanwu (RCW) and processed chuanwu (PCW) alone, as well as CW coadministered with BX on CYP3A activity.
Buspirone (BP) and testosterone (Tes) were used as specific probe substrates in vivo and ex vivo, respectively.
CYP3A activity was determined by the metabolites formation ratios from the substrates.
Compared with those in the control group, the metabolites formation ratios significantly decreased in the RCW and PCW alone groups, accompanied by a marked decrease in CYP3A protein and mRNA levels.
However, there was a significant increase in those ratios in the RCW-BX and PCW-BX groups compared to the RCW and PCW alone groups.
The results indicated that both RCW and PCW can inhibit CYP3A activity in rats because of downregulation of CYP3A protein and mRNA levels.
Decreases in CYP3A activity can be reversed by coadministration with BX.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wu, Jinjun& Cheng, Zaixing& Zhu, Lijun& Lu, Lin-lin& Zhang, Guiyu& Wang, Ying…[et al.]. 2014. Coadministration of Pinellia ternata Can Significantly Reduce Aconitum carmichaelii to Inhibit CYP3A Activity in Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1035352
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wu, Jinjun…[et al.]. Coadministration of Pinellia ternata Can Significantly Reduce Aconitum carmichaelii to Inhibit CYP3A Activity in Rats. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-1035352
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wu, Jinjun& Cheng, Zaixing& Zhu, Lijun& Lu, Lin-lin& Zhang, Guiyu& Wang, Ying…[et al.]. Coadministration of Pinellia ternata Can Significantly Reduce Aconitum carmichaelii to Inhibit CYP3A Activity in Rats. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1035352
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1035352
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر