Coadministration of Pinellia ternata Can Significantly Reduce Aconitum carmichaelii to Inhibit CYP3A Activity in Rats
Joint Authors
Xu, Ying
Wu, Jinjun
Cheng, Zaixing
Zhu, Lijun
Zhang, Guiyu
Wang, Ying
Liu, Zhong-Qiu
Lin, Na
Lu, Lin-lin
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-10-13
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Chuanwu (CW), the mother root of Aconitum carmichaelii Debx., is a traditional Chinese medicine (TCM) for treating traumatic injuries, rheumatoid arthritis, and tumors.
CW coadministered with banxia (BX), the root of Pinellia ternata, is also widely prescribed in clinical practice.
However, the mechanism of this combination is yet deciphered.
Current study aimed to investigate the effects of CW, including raw chuanwu (RCW) and processed chuanwu (PCW) alone, as well as CW coadministered with BX on CYP3A activity.
Buspirone (BP) and testosterone (Tes) were used as specific probe substrates in vivo and ex vivo, respectively.
CYP3A activity was determined by the metabolites formation ratios from the substrates.
Compared with those in the control group, the metabolites formation ratios significantly decreased in the RCW and PCW alone groups, accompanied by a marked decrease in CYP3A protein and mRNA levels.
However, there was a significant increase in those ratios in the RCW-BX and PCW-BX groups compared to the RCW and PCW alone groups.
The results indicated that both RCW and PCW can inhibit CYP3A activity in rats because of downregulation of CYP3A protein and mRNA levels.
Decreases in CYP3A activity can be reversed by coadministration with BX.
American Psychological Association (APA)
Wu, Jinjun& Cheng, Zaixing& Zhu, Lijun& Lu, Lin-lin& Zhang, Guiyu& Wang, Ying…[et al.]. 2014. Coadministration of Pinellia ternata Can Significantly Reduce Aconitum carmichaelii to Inhibit CYP3A Activity in Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1035352
Modern Language Association (MLA)
Wu, Jinjun…[et al.]. Coadministration of Pinellia ternata Can Significantly Reduce Aconitum carmichaelii to Inhibit CYP3A Activity in Rats. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-1035352
American Medical Association (AMA)
Wu, Jinjun& Cheng, Zaixing& Zhu, Lijun& Lu, Lin-lin& Zhang, Guiyu& Wang, Ying…[et al.]. Coadministration of Pinellia ternata Can Significantly Reduce Aconitum carmichaelii to Inhibit CYP3A Activity in Rats. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1035352
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1035352