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Yiqi Huoxue Recipe Improves Heart Function through Inhibiting Apoptosis Related to Endoplasmic Reticulum Stress in Myocardial Infarction Model of Rats
المؤلفون المشاركون
Ai-Ming, Wu
Gao, Yonghong
Wu, Sheng-Xian
Nie, Bo
Jin, Qiu-Shuo
Zhao, Yi-Zhou
Wang, Shuoren
Zhao, Mingjing
Chai, Limin
Li-Xia, Lou
Lv, Xiying
Zhang, Dong-mei
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-04-17
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Objective.
To explore the mechanism of cardioprotective effects of Chinese medicine, Yiqi Huoxue recipe, in rats with myocardial infarction- (MI-) induced heart failure.
Methods.
Male Sprague-Dawley rats underwent left anterior descending artery (LAD) ligation or sham operation.
The surviving MI rats were divided randomly into three groups: MI (5 mL/kg/d NS by gavage), MI + Metoprolol Tartrate (MT) (12 mg/kg/d MT by gavage), and MI + Yiqi Huoxue (5 mL/kg recipe by gavage).
And the sham operation rats were given 5 mL/kg/d normal saline.
Treatments were given on the day following surgery for 4 weeks.
Then rats were detected for heart structure and function by transthoracic echocardiography.
Apoptosis in heart tissues was detected by TUNEL staining.
To determine whether the endoplasmic reticulum (ER) stress response pathway is included in the cardioprotective function of the recipe, ER stress related proteins such as GRP78 and caspase-12 were examined.
Results.
Yiqi Huoxue recipe attenuated heart function injury, reversed histopathological damage, alleviated myocardial apoptosis and inhibited ER stress in MI rats.
Conclusion.
All the results suggest that Yiqi Huoxue recipe improves the injured heart function maybe through inhibition of ER stress response pathway, which is a promising target in therapy for heart failure.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Li-Xia, Lou& Ai-Ming, Wu& Zhang, Dong-mei& Wu, Sheng-Xian& Gao, Yonghong& Nie, Bo…[et al.]. 2014. Yiqi Huoxue Recipe Improves Heart Function through Inhibiting Apoptosis Related to Endoplasmic Reticulum Stress in Myocardial Infarction Model of Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1035357
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Li-Xia, Lou…[et al.]. Yiqi Huoxue Recipe Improves Heart Function through Inhibiting Apoptosis Related to Endoplasmic Reticulum Stress in Myocardial Infarction Model of Rats. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-1035357
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Li-Xia, Lou& Ai-Ming, Wu& Zhang, Dong-mei& Wu, Sheng-Xian& Gao, Yonghong& Nie, Bo…[et al.]. Yiqi Huoxue Recipe Improves Heart Function through Inhibiting Apoptosis Related to Endoplasmic Reticulum Stress in Myocardial Infarction Model of Rats. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1035357
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1035357
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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