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Yiqi Huoxue Recipe Improves Heart Function through Inhibiting Apoptosis Related to Endoplasmic Reticulum Stress in Myocardial Infarction Model of Rats
Joint Authors
Ai-Ming, Wu
Gao, Yonghong
Wu, Sheng-Xian
Nie, Bo
Jin, Qiu-Shuo
Zhao, Yi-Zhou
Wang, Shuoren
Zhao, Mingjing
Chai, Limin
Li-Xia, Lou
Lv, Xiying
Zhang, Dong-mei
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-17
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Objective.
To explore the mechanism of cardioprotective effects of Chinese medicine, Yiqi Huoxue recipe, in rats with myocardial infarction- (MI-) induced heart failure.
Methods.
Male Sprague-Dawley rats underwent left anterior descending artery (LAD) ligation or sham operation.
The surviving MI rats were divided randomly into three groups: MI (5 mL/kg/d NS by gavage), MI + Metoprolol Tartrate (MT) (12 mg/kg/d MT by gavage), and MI + Yiqi Huoxue (5 mL/kg recipe by gavage).
And the sham operation rats were given 5 mL/kg/d normal saline.
Treatments were given on the day following surgery for 4 weeks.
Then rats were detected for heart structure and function by transthoracic echocardiography.
Apoptosis in heart tissues was detected by TUNEL staining.
To determine whether the endoplasmic reticulum (ER) stress response pathway is included in the cardioprotective function of the recipe, ER stress related proteins such as GRP78 and caspase-12 were examined.
Results.
Yiqi Huoxue recipe attenuated heart function injury, reversed histopathological damage, alleviated myocardial apoptosis and inhibited ER stress in MI rats.
Conclusion.
All the results suggest that Yiqi Huoxue recipe improves the injured heart function maybe through inhibition of ER stress response pathway, which is a promising target in therapy for heart failure.
American Psychological Association (APA)
Li-Xia, Lou& Ai-Ming, Wu& Zhang, Dong-mei& Wu, Sheng-Xian& Gao, Yonghong& Nie, Bo…[et al.]. 2014. Yiqi Huoxue Recipe Improves Heart Function through Inhibiting Apoptosis Related to Endoplasmic Reticulum Stress in Myocardial Infarction Model of Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1035357
Modern Language Association (MLA)
Li-Xia, Lou…[et al.]. Yiqi Huoxue Recipe Improves Heart Function through Inhibiting Apoptosis Related to Endoplasmic Reticulum Stress in Myocardial Infarction Model of Rats. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-1035357
American Medical Association (AMA)
Li-Xia, Lou& Ai-Ming, Wu& Zhang, Dong-mei& Wu, Sheng-Xian& Gao, Yonghong& Nie, Bo…[et al.]. Yiqi Huoxue Recipe Improves Heart Function through Inhibiting Apoptosis Related to Endoplasmic Reticulum Stress in Myocardial Infarction Model of Rats. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1035357
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1035357