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Randomized, Double-Blind Clinical Trial to Assess the Acute Diuretic Effect of Equisetum arvense (Field Horsetail) in Healthy Volunteers
المؤلفون المشاركون
da Cunha, Luiz Carlos
Carneiro, Danilo Maciel
Freire, Ramias Calixto
Honório, Tereza Cristina de Deus
Zoghaib, Iury
Cardoso, Fabiana Fernandes de S. e Silva
Tresvenzol, Leonice Manrique F.
Sousa, Ana Luiza Lima
Jardim, Paulo César Brandão Veiga
de Paula, Jose Realino
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-03-04
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
In this double-blind, randomized clinical trial, 36 healthy male volunteers were randomly distributed into three groups ( n = 12 ) that underwent a three-step treatment.
For four consecutive days, we alternately administered a standardized dried extract of Equisetum arvense (EADE, 900 mg/day), placebo (corn starch, 900 mg/day), or hydrochlorothiazide (25 mg/day), separated by a 10-day washout period.
Each volunteer served as his own control, and the groups’ results were compared.
We repeated the same evaluation after each stage of treatment to evaluate the safety of the drug.
The diuretic effect of EADE was assessed by monitoring the volunteers’ water balance over a 24 h period.
The E.
arvense extract produced a diuretic effect that was stronger than that of the negative control and was equivalent to that of hydrochlorothiazide without causing significant changes in the elimination of electrolytes.
There was no significant increase in the urinary elimination of catabolites.
Rare minor adverse events were reported.
The clinical examinations and laboratory tests showed no changes before or after the experiment, suggesting that the drug is safe for acute use.
Further research is needed to better clarify the mechanism of diuretic action and the other possible pharmacological actions of this phytomedicine.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Carneiro, Danilo Maciel& Freire, Ramias Calixto& Honório, Tereza Cristina de Deus& Zoghaib, Iury& Cardoso, Fabiana Fernandes de S. e Silva& Tresvenzol, Leonice Manrique F.…[et al.]. 2014. Randomized, Double-Blind Clinical Trial to Assess the Acute Diuretic Effect of Equisetum arvense (Field Horsetail) in Healthy Volunteers. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1035360
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Carneiro, Danilo Maciel…[et al.]. Randomized, Double-Blind Clinical Trial to Assess the Acute Diuretic Effect of Equisetum arvense (Field Horsetail) in Healthy Volunteers. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-1035360
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Carneiro, Danilo Maciel& Freire, Ramias Calixto& Honório, Tereza Cristina de Deus& Zoghaib, Iury& Cardoso, Fabiana Fernandes de S. e Silva& Tresvenzol, Leonice Manrique F.…[et al.]. Randomized, Double-Blind Clinical Trial to Assess the Acute Diuretic Effect of Equisetum arvense (Field Horsetail) in Healthy Volunteers. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1035360
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1035360
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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