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Randomized, Double-Blind Clinical Trial to Assess the Acute Diuretic Effect of Equisetum arvense (Field Horsetail) in Healthy Volunteers
Joint Authors
da Cunha, Luiz Carlos
Carneiro, Danilo Maciel
Freire, Ramias Calixto
Honório, Tereza Cristina de Deus
Zoghaib, Iury
Cardoso, Fabiana Fernandes de S. e Silva
Tresvenzol, Leonice Manrique F.
Sousa, Ana Luiza Lima
Jardim, Paulo César Brandão Veiga
de Paula, Jose Realino
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-03-04
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
In this double-blind, randomized clinical trial, 36 healthy male volunteers were randomly distributed into three groups ( n = 12 ) that underwent a three-step treatment.
For four consecutive days, we alternately administered a standardized dried extract of Equisetum arvense (EADE, 900 mg/day), placebo (corn starch, 900 mg/day), or hydrochlorothiazide (25 mg/day), separated by a 10-day washout period.
Each volunteer served as his own control, and the groups’ results were compared.
We repeated the same evaluation after each stage of treatment to evaluate the safety of the drug.
The diuretic effect of EADE was assessed by monitoring the volunteers’ water balance over a 24 h period.
The E.
arvense extract produced a diuretic effect that was stronger than that of the negative control and was equivalent to that of hydrochlorothiazide without causing significant changes in the elimination of electrolytes.
There was no significant increase in the urinary elimination of catabolites.
Rare minor adverse events were reported.
The clinical examinations and laboratory tests showed no changes before or after the experiment, suggesting that the drug is safe for acute use.
Further research is needed to better clarify the mechanism of diuretic action and the other possible pharmacological actions of this phytomedicine.
American Psychological Association (APA)
Carneiro, Danilo Maciel& Freire, Ramias Calixto& Honório, Tereza Cristina de Deus& Zoghaib, Iury& Cardoso, Fabiana Fernandes de S. e Silva& Tresvenzol, Leonice Manrique F.…[et al.]. 2014. Randomized, Double-Blind Clinical Trial to Assess the Acute Diuretic Effect of Equisetum arvense (Field Horsetail) in Healthy Volunteers. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1035360
Modern Language Association (MLA)
Carneiro, Danilo Maciel…[et al.]. Randomized, Double-Blind Clinical Trial to Assess the Acute Diuretic Effect of Equisetum arvense (Field Horsetail) in Healthy Volunteers. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-1035360
American Medical Association (AMA)
Carneiro, Danilo Maciel& Freire, Ramias Calixto& Honório, Tereza Cristina de Deus& Zoghaib, Iury& Cardoso, Fabiana Fernandes de S. e Silva& Tresvenzol, Leonice Manrique F.…[et al.]. Randomized, Double-Blind Clinical Trial to Assess the Acute Diuretic Effect of Equisetum arvense (Field Horsetail) in Healthy Volunteers. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1035360
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1035360