Effects of 6-Hydroxyflavone on Osteoblast Differentiation in MC3T3-E1 Cells
المؤلفون المشاركون
Lai, Chien-Hung
Wu, Yu-Wei
Yeh, Shauh-Der
Lin, Yu-Hsaing
Tsai, Yu-Hui
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-03-26
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Osteoblast differentiation plays an essential role in bone integrity.
Isoflavones and some flavonoids are reported to have osteogenic activity and potentially possess the ability to treat osteoporosis.
However, limited information concerning the osteogenic characteristics of hydroxyflavones is available.
This study investigates the effects of various hydroxyflavones on osteoblast differentiation in MC3T3-E1 cells.
The results showed that 6-hydroxyflavone (6-OH-F) and 7-hydroxyflavone (7-OH-F) stimulated ALP activity.
However, baicalein and luteolin inhibited ALP activity and flavone showed no effect.
Up to 50 μM of each compound was used for cytotoxic effects study; flavone, 6-OH-F, and 7-OH-F had no cytotoxicity on MC3T3-E1 cells.
Moreover, 6-OH-F activated AKT and serine/threonine kinases (also known as protein kinase B or PKB), extracellular signal-regulated kinases (ERK 1/2), and the c-Jun N-terminal kinase (JNK) signaling pathways.
On the other hand, 7-OH-F promoted osteoblast differentiation mainly by activating ERK 1/ 2 signaling pathways.
Finally, after 5 weeks of 6-OH-F induction, MC3T3-E1 cells showed a significant increase in the calcein staining intensity relative to merely visible mineralization observed in cells cultured in the osteogenic medium only.
These results suggested that 6-OH-F could activate AKT, ERK 1/2, and JNK signaling pathways to effectively promote osteoblastic differentiation.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Lai, Chien-Hung& Wu, Yu-Wei& Yeh, Shauh-Der& Lin, Yu-Hsaing& Tsai, Yu-Hui. 2014. Effects of 6-Hydroxyflavone on Osteoblast Differentiation in MC3T3-E1 Cells. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1035455
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Lai, Chien-Hung…[et al.]. Effects of 6-Hydroxyflavone on Osteoblast Differentiation in MC3T3-E1 Cells. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-1035455
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Lai, Chien-Hung& Wu, Yu-Wei& Yeh, Shauh-Der& Lin, Yu-Hsaing& Tsai, Yu-Hui. Effects of 6-Hydroxyflavone on Osteoblast Differentiation in MC3T3-E1 Cells. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1035455
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1035455
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر