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Hepatoprotective Effect of Pretreatment with Thymus vulgaris Essential Oil in Experimental Model of Acetaminophen-Induced Injury
المؤلفون المشاركون
Cuman, Roberto Kenji Nakamura
Silva, Expedito Leite
Grespan, Renata
Aguiar, Rafael Pazinatto
Giubilei, Frederico Nunes
Fuso, Rafael Rocco
Damião, Marcio José
Mikcha, Jane Graton
Hernandes, Luzmarina
Bersani-Amado, Ciomar Aparecida
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-02-04
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Acute liver damage caused by acetaminophen overdose is a significant clinical problem and could benefit from new therapeutic strategies.
Objective.
This study investigated the hepatoprotective effect of Thymus vulgaris essential oil (TEO), which is used popularly for various beneficial effects, such as its antiseptic, carminative, and antimicrobial effects.
The hepatoprotective activity of TEO was determined by assessing serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), and alkaline phosphatase (ALP) in mice.
Their livers were then used to determine myeloperoxidase (MPO) enzyme activity and subjected to histological analysis.
In vitro antioxidant activity was evaluated by assessing the free radical 2,2-diphenyl-1-picrylhydrazyl (DPPH•)-scavenging effects of TEO and TEO-induced lipid peroxidation.
TEO reduced the levels of the serum marker enzymes AST, ALT, and ALP and MPO activity.
The histopathological analysis indicated that TEO prevented acetaminophen-induced necrosis.
The essential oil also exhibited antioxidant activity, reflected by its DPPH radical-scavenging effects and in the lipid peroxidation assay.
These results suggest that TEO has hepatoprotective effects on acetaminophen-induced hepatic damage in mice.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Grespan, Renata& Aguiar, Rafael Pazinatto& Giubilei, Frederico Nunes& Fuso, Rafael Rocco& Damião, Marcio José& Silva, Expedito Leite…[et al.]. 2014. Hepatoprotective Effect of Pretreatment with Thymus vulgaris Essential Oil in Experimental Model of Acetaminophen-Induced Injury. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1035479
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Grespan, Renata…[et al.]. Hepatoprotective Effect of Pretreatment with Thymus vulgaris Essential Oil in Experimental Model of Acetaminophen-Induced Injury. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-1035479
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Grespan, Renata& Aguiar, Rafael Pazinatto& Giubilei, Frederico Nunes& Fuso, Rafael Rocco& Damião, Marcio José& Silva, Expedito Leite…[et al.]. Hepatoprotective Effect of Pretreatment with Thymus vulgaris Essential Oil in Experimental Model of Acetaminophen-Induced Injury. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1035479
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1035479
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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