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Hepatoprotective Effect of Pretreatment with Thymus vulgaris Essential Oil in Experimental Model of Acetaminophen-Induced Injury
Joint Authors
Cuman, Roberto Kenji Nakamura
Silva, Expedito Leite
Grespan, Renata
Aguiar, Rafael Pazinatto
Giubilei, Frederico Nunes
Fuso, Rafael Rocco
Damião, Marcio José
Mikcha, Jane Graton
Hernandes, Luzmarina
Bersani-Amado, Ciomar Aparecida
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-02-04
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Acute liver damage caused by acetaminophen overdose is a significant clinical problem and could benefit from new therapeutic strategies.
Objective.
This study investigated the hepatoprotective effect of Thymus vulgaris essential oil (TEO), which is used popularly for various beneficial effects, such as its antiseptic, carminative, and antimicrobial effects.
The hepatoprotective activity of TEO was determined by assessing serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), and alkaline phosphatase (ALP) in mice.
Their livers were then used to determine myeloperoxidase (MPO) enzyme activity and subjected to histological analysis.
In vitro antioxidant activity was evaluated by assessing the free radical 2,2-diphenyl-1-picrylhydrazyl (DPPH•)-scavenging effects of TEO and TEO-induced lipid peroxidation.
TEO reduced the levels of the serum marker enzymes AST, ALT, and ALP and MPO activity.
The histopathological analysis indicated that TEO prevented acetaminophen-induced necrosis.
The essential oil also exhibited antioxidant activity, reflected by its DPPH radical-scavenging effects and in the lipid peroxidation assay.
These results suggest that TEO has hepatoprotective effects on acetaminophen-induced hepatic damage in mice.
American Psychological Association (APA)
Grespan, Renata& Aguiar, Rafael Pazinatto& Giubilei, Frederico Nunes& Fuso, Rafael Rocco& Damião, Marcio José& Silva, Expedito Leite…[et al.]. 2014. Hepatoprotective Effect of Pretreatment with Thymus vulgaris Essential Oil in Experimental Model of Acetaminophen-Induced Injury. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1035479
Modern Language Association (MLA)
Grespan, Renata…[et al.]. Hepatoprotective Effect of Pretreatment with Thymus vulgaris Essential Oil in Experimental Model of Acetaminophen-Induced Injury. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-1035479
American Medical Association (AMA)
Grespan, Renata& Aguiar, Rafael Pazinatto& Giubilei, Frederico Nunes& Fuso, Rafael Rocco& Damião, Marcio José& Silva, Expedito Leite…[et al.]. Hepatoprotective Effect of Pretreatment with Thymus vulgaris Essential Oil in Experimental Model of Acetaminophen-Induced Injury. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1035479
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1035479