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Suxiao Jiuxin Pill Induces Potent Relaxation and Inhibition on Contraction in Human Artery and the Mechanism
المؤلفون المشاركون
He, Guo-Wei
Bai, Xiao-Yan
Zhang, Ping
Yang, Qin
Liu, Xiao-Cheng
Wang, Jun
Tong, Yong-Ling
Xiong, Song-Jin
Liu, Li-Hua
Wang, Lei
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-04-07
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Suxiao Jiuxin Pill, a compound Chinese traditional medicine with main components of tetramethylpyrazine and borneol, is widely used for antiangina treatment in China but its pharmacological effect on human blood vessels is unknown.
We investigated the effect and possible mechanism of SJP in the human internal mammary artery (IMA, n = 78 ) taken from patients undergoing coronary surgery.
SJP caused full relaxation in KCl- ( 99.4 ± 10.5 %, n = 6 ) and U46619- ( 99.9 ± 5.6 %, n = 6 ) contracted IMA.
Pretreatment of IMA with plasma concentrations of SJP (1 mg/mL), calculated from the plasma concentration of its major component borneol, significantly depressed the maximal contraction to KCl (from 35.8 ± 6.0 mN to 12.6 ± 5.6 mN, P = 0.03 ) and U46619 (from 19.4 ± 2.9 mN to 5.7 ± 2.4 mN, P = 0.007 ) while SJP at 10 mg/mL abolished the subsequent contraction.
Endothelium denudation and inhibition of eNOS significantly altered the SJP-induced relaxation without changes of eNOS expression.
We conclude that SJP has a potent inhibitory effect on the vasoconstriction mediated by a variety of vasoconstrictors in human arteries.
The vasorelaxation involves both endothelium-dependent and -independent mechanisms.
Thus, the effect of SJP on human arteries demonstrated in this study may prove to be particularly important in vasorelaxing therapy in cardiovascular disease.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Bai, Xiao-Yan& Zhang, Ping& Yang, Qin& Liu, Xiao-Cheng& Wang, Jun& Tong, Yong-Ling…[et al.]. 2014. Suxiao Jiuxin Pill Induces Potent Relaxation and Inhibition on Contraction in Human Artery and the Mechanism. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1035483
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Bai, Xiao-Yan…[et al.]. Suxiao Jiuxin Pill Induces Potent Relaxation and Inhibition on Contraction in Human Artery and the Mechanism. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-1035483
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Bai, Xiao-Yan& Zhang, Ping& Yang, Qin& Liu, Xiao-Cheng& Wang, Jun& Tong, Yong-Ling…[et al.]. Suxiao Jiuxin Pill Induces Potent Relaxation and Inhibition on Contraction in Human Artery and the Mechanism. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1035483
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1035483
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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