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Suxiao Jiuxin Pill Induces Potent Relaxation and Inhibition on Contraction in Human Artery and the Mechanism
Joint Authors
He, Guo-Wei
Bai, Xiao-Yan
Zhang, Ping
Yang, Qin
Liu, Xiao-Cheng
Wang, Jun
Tong, Yong-Ling
Xiong, Song-Jin
Liu, Li-Hua
Wang, Lei
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-07
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Suxiao Jiuxin Pill, a compound Chinese traditional medicine with main components of tetramethylpyrazine and borneol, is widely used for antiangina treatment in China but its pharmacological effect on human blood vessels is unknown.
We investigated the effect and possible mechanism of SJP in the human internal mammary artery (IMA, n = 78 ) taken from patients undergoing coronary surgery.
SJP caused full relaxation in KCl- ( 99.4 ± 10.5 %, n = 6 ) and U46619- ( 99.9 ± 5.6 %, n = 6 ) contracted IMA.
Pretreatment of IMA with plasma concentrations of SJP (1 mg/mL), calculated from the plasma concentration of its major component borneol, significantly depressed the maximal contraction to KCl (from 35.8 ± 6.0 mN to 12.6 ± 5.6 mN, P = 0.03 ) and U46619 (from 19.4 ± 2.9 mN to 5.7 ± 2.4 mN, P = 0.007 ) while SJP at 10 mg/mL abolished the subsequent contraction.
Endothelium denudation and inhibition of eNOS significantly altered the SJP-induced relaxation without changes of eNOS expression.
We conclude that SJP has a potent inhibitory effect on the vasoconstriction mediated by a variety of vasoconstrictors in human arteries.
The vasorelaxation involves both endothelium-dependent and -independent mechanisms.
Thus, the effect of SJP on human arteries demonstrated in this study may prove to be particularly important in vasorelaxing therapy in cardiovascular disease.
American Psychological Association (APA)
Bai, Xiao-Yan& Zhang, Ping& Yang, Qin& Liu, Xiao-Cheng& Wang, Jun& Tong, Yong-Ling…[et al.]. 2014. Suxiao Jiuxin Pill Induces Potent Relaxation and Inhibition on Contraction in Human Artery and the Mechanism. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1035483
Modern Language Association (MLA)
Bai, Xiao-Yan…[et al.]. Suxiao Jiuxin Pill Induces Potent Relaxation and Inhibition on Contraction in Human Artery and the Mechanism. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-1035483
American Medical Association (AMA)
Bai, Xiao-Yan& Zhang, Ping& Yang, Qin& Liu, Xiao-Cheng& Wang, Jun& Tong, Yong-Ling…[et al.]. Suxiao Jiuxin Pill Induces Potent Relaxation and Inhibition on Contraction in Human Artery and the Mechanism. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1035483
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1035483