Cognitive Enhancing and Neuroprotective Effect of the Embryo of the Nelumbo nucifera Seed
المؤلفون المشاركون
Eom, Min Rye
Ma, Choong Je
Lee, Jiwoo
Kim, Eun Sil
Oh, Kyoung-Hee
Yun, Bo-Ra
Weon, Jin Bae
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-12-24
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
The aim of the present study was to evaluate the effect of ENS on cognitive impairment induced by scopolamine and its potential neuroprotective effect against glutamate-induced cytotoxicity in HT22 cell and to investigate the underlying mechanisms.
ENS (3, 10, 30, and 100 mg/kg), scopolamine (1 mg/kg), and donepezil (1 mg/kg) were administered to mice during a test period.
Scopolamine impaired memory and learning in a water maze test and a passive avoidance test.
The neuroprotective effect of ENS (10 and 100 μg/mL) was investigated on glutamate-induced cell death in HT22 cells by MTT assay.
We investigated acetylcholinesterase inhibition in hippocampus and antioxidant activity, ROS levels, and Ca2+ influx in HT22 cells to elucidate the potential mechanisms of ENS.
We found that ENS significantly ameliorated scopolamine-induced memory impairment and inhibited AChE activity in hippocampus.
In vitro, ENS showed potent neuroprotective effects against glutamate-induced neurotoxicity in the HT22 cell.
In addition, ENS induced a decrease in ROS production and intercellular Ca2+ accumulation and showed DPPH radical and H2O2 scavenging activity.
In conclusion, ENS showed both a memory improving effect and a neuroprotective effect.
Our results indicate that ENS may be of use in the treatment and prevention of neurodegenerative disorders.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kim, Eun Sil& Weon, Jin Bae& Yun, Bo-Ra& Lee, Jiwoo& Eom, Min Rye& Oh, Kyoung-Hee…[et al.]. 2014. Cognitive Enhancing and Neuroprotective Effect of the Embryo of the Nelumbo nucifera Seed. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1035832
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kim, Eun Sil…[et al.]. Cognitive Enhancing and Neuroprotective Effect of the Embryo of the Nelumbo nucifera Seed. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-1035832
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kim, Eun Sil& Weon, Jin Bae& Yun, Bo-Ra& Lee, Jiwoo& Eom, Min Rye& Oh, Kyoung-Hee…[et al.]. Cognitive Enhancing and Neuroprotective Effect of the Embryo of the Nelumbo nucifera Seed. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1035832
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1035832
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر