Cognitive Enhancing and Neuroprotective Effect of the Embryo of the Nelumbo nucifera Seed
Joint Authors
Eom, Min Rye
Ma, Choong Je
Lee, Jiwoo
Kim, Eun Sil
Oh, Kyoung-Hee
Yun, Bo-Ra
Weon, Jin Bae
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-12-24
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The aim of the present study was to evaluate the effect of ENS on cognitive impairment induced by scopolamine and its potential neuroprotective effect against glutamate-induced cytotoxicity in HT22 cell and to investigate the underlying mechanisms.
ENS (3, 10, 30, and 100 mg/kg), scopolamine (1 mg/kg), and donepezil (1 mg/kg) were administered to mice during a test period.
Scopolamine impaired memory and learning in a water maze test and a passive avoidance test.
The neuroprotective effect of ENS (10 and 100 μg/mL) was investigated on glutamate-induced cell death in HT22 cells by MTT assay.
We investigated acetylcholinesterase inhibition in hippocampus and antioxidant activity, ROS levels, and Ca2+ influx in HT22 cells to elucidate the potential mechanisms of ENS.
We found that ENS significantly ameliorated scopolamine-induced memory impairment and inhibited AChE activity in hippocampus.
In vitro, ENS showed potent neuroprotective effects against glutamate-induced neurotoxicity in the HT22 cell.
In addition, ENS induced a decrease in ROS production and intercellular Ca2+ accumulation and showed DPPH radical and H2O2 scavenging activity.
In conclusion, ENS showed both a memory improving effect and a neuroprotective effect.
Our results indicate that ENS may be of use in the treatment and prevention of neurodegenerative disorders.
American Psychological Association (APA)
Kim, Eun Sil& Weon, Jin Bae& Yun, Bo-Ra& Lee, Jiwoo& Eom, Min Rye& Oh, Kyoung-Hee…[et al.]. 2014. Cognitive Enhancing and Neuroprotective Effect of the Embryo of the Nelumbo nucifera Seed. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1035832
Modern Language Association (MLA)
Kim, Eun Sil…[et al.]. Cognitive Enhancing and Neuroprotective Effect of the Embryo of the Nelumbo nucifera Seed. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-1035832
American Medical Association (AMA)
Kim, Eun Sil& Weon, Jin Bae& Yun, Bo-Ra& Lee, Jiwoo& Eom, Min Rye& Oh, Kyoung-Hee…[et al.]. Cognitive Enhancing and Neuroprotective Effect of the Embryo of the Nelumbo nucifera Seed. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1035832
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1035832