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Clinical Study on Prospective Efficacy of All-Trans Acid, Realgar-Indigo Naturalis Formula Combined with Chemotherapy as Maintenance Treatment of Acute Promyelocytic Leukemia
المؤلفون المشاركون
Xiang-Xin, Li
Lu-Qun, Wang
Hao, Li
Xiao-Peng, He
Fang-Lin, Li
Ling-Ling, Wang
Xue-Liang, Chen
Ming, Hou
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-05-27
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Objectives.
To test the efficiency and safety of sequential application of retinoic acid (ATRA), Realgar-Indigo naturalis formula (RIF) and chemotherapy (CT) were used as the maintenance treatment in patients with acute promyelocytic leukemia (APL).
Methods.
This was a retrospective study of 98 patients with newly diagnosed APL who accepted two different maintenance treatments.
After remission induction and consolidation chemotherapy according to their Sanz scores, patients received two different kinds of maintenance scheme.
The first regimen was using ATRA, RIF, and standard dose of CT sequentially (ATRA/RIF/CT regimen), while the second one was using ATRA and low dose of chemotherapy with methotrexate (MTX) plus 6-mercaptopurine (6-MP) alternately (ATRA/CTlow regimen).
The OS, DFS, relapse rate, minimal residual disease, and adverse reactions in two groups were monitored and evaluated.
Results.
ATRA/RIF/CT regimen could effectively reduce the chance of relapse in different risk stratification of patients, but there was no significant difference in 5-year DFS rate and OS rate between the two groups.
Besides, the patients in the experimental group suffered less severe adverse reactions than those in the control group.
Conclusions.
The repeated sequential therapeutic regimen to APL with ATRA, RIF, and chemotherapy is worth popularizing for its high effectiveness and low toxicity.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Xiang-Xin, Li& Lu-Qun, Wang& Hao, Li& Xiao-Peng, He& Fang-Lin, Li& Ling-Ling, Wang…[et al.]. 2014. Clinical Study on Prospective Efficacy of All-Trans Acid, Realgar-Indigo Naturalis Formula Combined with Chemotherapy as Maintenance Treatment of Acute Promyelocytic Leukemia. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1035836
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Xiang-Xin, Li…[et al.]. Clinical Study on Prospective Efficacy of All-Trans Acid, Realgar-Indigo Naturalis Formula Combined with Chemotherapy as Maintenance Treatment of Acute Promyelocytic Leukemia. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-1035836
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Xiang-Xin, Li& Lu-Qun, Wang& Hao, Li& Xiao-Peng, He& Fang-Lin, Li& Ling-Ling, Wang…[et al.]. Clinical Study on Prospective Efficacy of All-Trans Acid, Realgar-Indigo Naturalis Formula Combined with Chemotherapy as Maintenance Treatment of Acute Promyelocytic Leukemia. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1035836
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1035836
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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