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Clinical Study on Prospective Efficacy of All-Trans Acid, Realgar-Indigo Naturalis Formula Combined with Chemotherapy as Maintenance Treatment of Acute Promyelocytic Leukemia
Joint Authors
Xiang-Xin, Li
Lu-Qun, Wang
Hao, Li
Xiao-Peng, He
Fang-Lin, Li
Ling-Ling, Wang
Xue-Liang, Chen
Ming, Hou
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-27
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Objectives.
To test the efficiency and safety of sequential application of retinoic acid (ATRA), Realgar-Indigo naturalis formula (RIF) and chemotherapy (CT) were used as the maintenance treatment in patients with acute promyelocytic leukemia (APL).
Methods.
This was a retrospective study of 98 patients with newly diagnosed APL who accepted two different maintenance treatments.
After remission induction and consolidation chemotherapy according to their Sanz scores, patients received two different kinds of maintenance scheme.
The first regimen was using ATRA, RIF, and standard dose of CT sequentially (ATRA/RIF/CT regimen), while the second one was using ATRA and low dose of chemotherapy with methotrexate (MTX) plus 6-mercaptopurine (6-MP) alternately (ATRA/CTlow regimen).
The OS, DFS, relapse rate, minimal residual disease, and adverse reactions in two groups were monitored and evaluated.
Results.
ATRA/RIF/CT regimen could effectively reduce the chance of relapse in different risk stratification of patients, but there was no significant difference in 5-year DFS rate and OS rate between the two groups.
Besides, the patients in the experimental group suffered less severe adverse reactions than those in the control group.
Conclusions.
The repeated sequential therapeutic regimen to APL with ATRA, RIF, and chemotherapy is worth popularizing for its high effectiveness and low toxicity.
American Psychological Association (APA)
Xiang-Xin, Li& Lu-Qun, Wang& Hao, Li& Xiao-Peng, He& Fang-Lin, Li& Ling-Ling, Wang…[et al.]. 2014. Clinical Study on Prospective Efficacy of All-Trans Acid, Realgar-Indigo Naturalis Formula Combined with Chemotherapy as Maintenance Treatment of Acute Promyelocytic Leukemia. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1035836
Modern Language Association (MLA)
Xiang-Xin, Li…[et al.]. Clinical Study on Prospective Efficacy of All-Trans Acid, Realgar-Indigo Naturalis Formula Combined with Chemotherapy as Maintenance Treatment of Acute Promyelocytic Leukemia. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-1035836
American Medical Association (AMA)
Xiang-Xin, Li& Lu-Qun, Wang& Hao, Li& Xiao-Peng, He& Fang-Lin, Li& Ling-Ling, Wang…[et al.]. Clinical Study on Prospective Efficacy of All-Trans Acid, Realgar-Indigo Naturalis Formula Combined with Chemotherapy as Maintenance Treatment of Acute Promyelocytic Leukemia. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1035836
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1035836