Rab27b Is a Potential Predictor for Metastasis and Prognosis in Colorectal Cancer
المؤلفون المشاركون
Ge, Zhijun
Zhan, Feng
Bao, Jun
Ni, Yijiang
Qin, Hui
Xu, Li
Zhu, Huijun
Zhao, Jiabi
Zhou, Xiaoli
Tang, Xiaojun
Tang, Liming
المصدر
Gastroenterology Research and Practice
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-12-15
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Objective.
Rab27b is reported to correlate with cancer development and progression.
However, the association between Rab27b expression and the clinical characteristics of colorectal cancer (CRC) is barely investigated.
Methods.
One-step quantitative reverse transcription-polymerase chain reaction (qPCR) test with 18 fresh-frozen CRC samples and immunohistochemistry (IHC) analysis in 113 CRC cases were performed to explore the relationship between Rab27b expression and the clinicopathological features of CRC.
Cox regression and Kaplan-Meier survival analyses were executed to evaluate the prognosis of CRC.
Results.
The results demonstrated that the expression levels of Rab27b mRNA and protein were significantly higher in CRC tissues than that in matched noncancerous tissues ( P < 0.05 ).
Rab27b protein expression in CRC was statistically correlated with serum CEA level ( P = 0.004 ), lymph node metastasis ( P = 0.001 ), distant metastasis ( P = 0.009 ), and TNM stage ( P = 0.001 ).
Cox multifactor analysis and Kaplan-Meier method suggested that higher Rab27b protein expression ( P = 0.041 ) and tumor differentiation ( P = 0.001 ) were significantly associated with the overall survival of CRC patients.
Conclusions.
The data indicated that higher expression of Rab27b was observed in CRC tissues and Rab27b may be identified as a useful predictor of metastasis and prognosis for CRC.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Bao, Jun& Ni, Yijiang& Qin, Hui& Xu, Li& Ge, Zhijun& Zhan, Feng…[et al.]. 2014. Rab27b Is a Potential Predictor for Metastasis and Prognosis in Colorectal Cancer. Gastroenterology Research and Practice،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1035909
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Bao, Jun…[et al.]. Rab27b Is a Potential Predictor for Metastasis and Prognosis in Colorectal Cancer. Gastroenterology Research and Practice No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-1035909
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Bao, Jun& Ni, Yijiang& Qin, Hui& Xu, Li& Ge, Zhijun& Zhan, Feng…[et al.]. Rab27b Is a Potential Predictor for Metastasis and Prognosis in Colorectal Cancer. Gastroenterology Research and Practice. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1035909
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1035909
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر