Rab27b Is a Potential Predictor for Metastasis and Prognosis in Colorectal Cancer
Joint Authors
Ge, Zhijun
Zhan, Feng
Bao, Jun
Ni, Yijiang
Qin, Hui
Xu, Li
Zhu, Huijun
Zhao, Jiabi
Zhou, Xiaoli
Tang, Xiaojun
Tang, Liming
Source
Gastroenterology Research and Practice
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-12-15
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Objective.
Rab27b is reported to correlate with cancer development and progression.
However, the association between Rab27b expression and the clinical characteristics of colorectal cancer (CRC) is barely investigated.
Methods.
One-step quantitative reverse transcription-polymerase chain reaction (qPCR) test with 18 fresh-frozen CRC samples and immunohistochemistry (IHC) analysis in 113 CRC cases were performed to explore the relationship between Rab27b expression and the clinicopathological features of CRC.
Cox regression and Kaplan-Meier survival analyses were executed to evaluate the prognosis of CRC.
Results.
The results demonstrated that the expression levels of Rab27b mRNA and protein were significantly higher in CRC tissues than that in matched noncancerous tissues ( P < 0.05 ).
Rab27b protein expression in CRC was statistically correlated with serum CEA level ( P = 0.004 ), lymph node metastasis ( P = 0.001 ), distant metastasis ( P = 0.009 ), and TNM stage ( P = 0.001 ).
Cox multifactor analysis and Kaplan-Meier method suggested that higher Rab27b protein expression ( P = 0.041 ) and tumor differentiation ( P = 0.001 ) were significantly associated with the overall survival of CRC patients.
Conclusions.
The data indicated that higher expression of Rab27b was observed in CRC tissues and Rab27b may be identified as a useful predictor of metastasis and prognosis for CRC.
American Psychological Association (APA)
Bao, Jun& Ni, Yijiang& Qin, Hui& Xu, Li& Ge, Zhijun& Zhan, Feng…[et al.]. 2014. Rab27b Is a Potential Predictor for Metastasis and Prognosis in Colorectal Cancer. Gastroenterology Research and Practice،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1035909
Modern Language Association (MLA)
Bao, Jun…[et al.]. Rab27b Is a Potential Predictor for Metastasis and Prognosis in Colorectal Cancer. Gastroenterology Research and Practice No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-1035909
American Medical Association (AMA)
Bao, Jun& Ni, Yijiang& Qin, Hui& Xu, Li& Ge, Zhijun& Zhan, Feng…[et al.]. Rab27b Is a Potential Predictor for Metastasis and Prognosis in Colorectal Cancer. Gastroenterology Research and Practice. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1035909
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1035909