Effect of Melatonin on Cognitive Function and Sleep in relation to Breast Cancer Surgery: A Randomized, Double-Blind, Placebo-Controlled Trial
المؤلفون المشاركون
Hansen, Melissa Voigt
Madsen, Michael Tvilling
Andersen, Lærke Toftegård
Hageman, Ida
Rasmussen, Lars Simon
Bokmand, Susanne
Gögenur, Ismail
Rosenberg, Jacob
المصدر
International Journal of Breast Cancer
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-08-26
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Background.
Sleep disturbances and cognitive dysfunction are common in patients with breast cancer.
Disturbed sleep leads to poor cognitive performance and exogenous melatonin may improve sleep and attenuate cognitive dysfunction.
We hypothesized that melatonin would improve sleep and cognitive function after surgery.
Methods.
This study reports secondary endpoints from a randomized, double-blind, placebo-controlled trial.
Women, 30–75 years, were randomized to 6mg oral melatonin/placebo for 3 months.
We assessed postoperative cognitive dysfunction (POCD) with a neuropsychological test battery, sleep with a diary, and sleep quality with VAS.
Results.
54 patients were randomized to melatonin ( n = 28 ) or placebo ( n = 26 ); 11 withdrew (10 placebo, 1 melatonin, P = 0.002 ).
The incidence of POCD was 0% (0/20) [95% CI 0.0%; 16.8%] in the placebo group and 0% (0/26) [95% CI 0.0%; 13.2%] in the melatonin group 2 weeks postoperatively ( P = 1.00 ) and 6.3% (1/16) [95% CI 0.0%; 30.2%] in the placebo group and 0% (0/26) [95% CI 0.0%; 13.2%] in the melatonin group 12 weeks postoperatively ( P = 0.38 ).
Sleep efficiency was significantly greater in the melatonin group; mean difference was 4.28% [95% CI 0.57; 7.82] ( P = 0.02 ).
The total sleep period was significantly longer in the melatonin group; mean difference was 37.0 min [95% CI 3.6; 69.7] ( P = 0.03 ).
Conclusion.
Melatonin increased sleep efficiency and total sleep time but did not affect cognitive function.
The dropout rate was significantly lower in the melatonin group.
This trial is registered with Clinicaltrials.gov NCT01355523.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Hansen, Melissa Voigt& Madsen, Michael Tvilling& Andersen, Lærke Toftegård& Hageman, Ida& Rasmussen, Lars Simon& Bokmand, Susanne…[et al.]. 2014. Effect of Melatonin on Cognitive Function and Sleep in relation to Breast Cancer Surgery: A Randomized, Double-Blind, Placebo-Controlled Trial. International Journal of Breast Cancer،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1036300
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Hansen, Melissa Voigt…[et al.]. Effect of Melatonin on Cognitive Function and Sleep in relation to Breast Cancer Surgery: A Randomized, Double-Blind, Placebo-Controlled Trial. International Journal of Breast Cancer No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-1036300
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Hansen, Melissa Voigt& Madsen, Michael Tvilling& Andersen, Lærke Toftegård& Hageman, Ida& Rasmussen, Lars Simon& Bokmand, Susanne…[et al.]. Effect of Melatonin on Cognitive Function and Sleep in relation to Breast Cancer Surgery: A Randomized, Double-Blind, Placebo-Controlled Trial. International Journal of Breast Cancer. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1036300
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1036300
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر