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Effect of Melatonin on Cognitive Function and Sleep in relation to Breast Cancer Surgery: A Randomized, Double-Blind, Placebo-Controlled Trial
Joint Authors
Hansen, Melissa Voigt
Madsen, Michael Tvilling
Andersen, Lærke Toftegård
Hageman, Ida
Rasmussen, Lars Simon
Bokmand, Susanne
Gögenur, Ismail
Rosenberg, Jacob
Source
International Journal of Breast Cancer
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-08-26
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Background.
Sleep disturbances and cognitive dysfunction are common in patients with breast cancer.
Disturbed sleep leads to poor cognitive performance and exogenous melatonin may improve sleep and attenuate cognitive dysfunction.
We hypothesized that melatonin would improve sleep and cognitive function after surgery.
Methods.
This study reports secondary endpoints from a randomized, double-blind, placebo-controlled trial.
Women, 30–75 years, were randomized to 6mg oral melatonin/placebo for 3 months.
We assessed postoperative cognitive dysfunction (POCD) with a neuropsychological test battery, sleep with a diary, and sleep quality with VAS.
Results.
54 patients were randomized to melatonin ( n = 28 ) or placebo ( n = 26 ); 11 withdrew (10 placebo, 1 melatonin, P = 0.002 ).
The incidence of POCD was 0% (0/20) [95% CI 0.0%; 16.8%] in the placebo group and 0% (0/26) [95% CI 0.0%; 13.2%] in the melatonin group 2 weeks postoperatively ( P = 1.00 ) and 6.3% (1/16) [95% CI 0.0%; 30.2%] in the placebo group and 0% (0/26) [95% CI 0.0%; 13.2%] in the melatonin group 12 weeks postoperatively ( P = 0.38 ).
Sleep efficiency was significantly greater in the melatonin group; mean difference was 4.28% [95% CI 0.57; 7.82] ( P = 0.02 ).
The total sleep period was significantly longer in the melatonin group; mean difference was 37.0 min [95% CI 3.6; 69.7] ( P = 0.03 ).
Conclusion.
Melatonin increased sleep efficiency and total sleep time but did not affect cognitive function.
The dropout rate was significantly lower in the melatonin group.
This trial is registered with Clinicaltrials.gov NCT01355523.
American Psychological Association (APA)
Hansen, Melissa Voigt& Madsen, Michael Tvilling& Andersen, Lærke Toftegård& Hageman, Ida& Rasmussen, Lars Simon& Bokmand, Susanne…[et al.]. 2014. Effect of Melatonin on Cognitive Function and Sleep in relation to Breast Cancer Surgery: A Randomized, Double-Blind, Placebo-Controlled Trial. International Journal of Breast Cancer،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1036300
Modern Language Association (MLA)
Hansen, Melissa Voigt…[et al.]. Effect of Melatonin on Cognitive Function and Sleep in relation to Breast Cancer Surgery: A Randomized, Double-Blind, Placebo-Controlled Trial. International Journal of Breast Cancer No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-1036300
American Medical Association (AMA)
Hansen, Melissa Voigt& Madsen, Michael Tvilling& Andersen, Lærke Toftegård& Hageman, Ida& Rasmussen, Lars Simon& Bokmand, Susanne…[et al.]. Effect of Melatonin on Cognitive Function and Sleep in relation to Breast Cancer Surgery: A Randomized, Double-Blind, Placebo-Controlled Trial. International Journal of Breast Cancer. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1036300
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1036300