![](/images/graphics-bg.png)
Recombinant Human Leptin Does Not Alter Gut Hormone Levels after Gastric Bypass but May Attenuate Sweet Cravings
المؤلفون المشاركون
Conroy, Rushika
Febres, Gerardo
McMahon, Donald J.
Thorner, Michael O.
Gaylinn, Bruce D.
Conwell, Irene
Aronne, Louis
Korner, Judith
المصدر
International Journal of Endocrinology
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-05-08
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Bariatric surgery improves glucose homeostasis and alters gut hormones partly independent of weight loss.
Leptin plays a role in these processes; levels are decreased following bariatric surgery, creating a relative leptin insufficiency.
We previously showed that leptin administration in a weight-reduced state after Roux-en-Y gastric bypass (RYGB) caused no further weight loss.
Here, we discuss the impact of leptin administration on gut hormones, glucostasis, and appetite.
Weight stable women after RYGB were randomized to receive placebo or recombinant human metreleptin (0.05 mg/kg twice daily).
At weeks 0 and 16, a liquid meal challenge was performed.
Glucose, insulin, C-peptide, GLP-1, PYY, glucagon, and ghrelin (total, acyl, and desacyl) were measured fasting and postprandially.
Appetite was assessed using a visual analog scale.
Mean post-op period was 53 ± 2.3 months; mean BMI was 34.6 ± 0.2 kg/m2.
At 16 weeks, there was no significant change in weight within or between groups.
Fasting PYY was significantly different between groups and the leptin group had lower sweets craving at week 16 than the placebo group ( P < 0.05 ).
No other differences were observed.
Leptin replacement does not alter gut hormones or glucostasis but may diminish sweet cravings compared to placebo in this population of post-RYGB women.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Conroy, Rushika& Febres, Gerardo& McMahon, Donald J.& Thorner, Michael O.& Gaylinn, Bruce D.& Conwell, Irene…[et al.]. 2014. Recombinant Human Leptin Does Not Alter Gut Hormone Levels after Gastric Bypass but May Attenuate Sweet Cravings. International Journal of Endocrinology،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1036412
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Conroy, Rushika…[et al.]. Recombinant Human Leptin Does Not Alter Gut Hormone Levels after Gastric Bypass but May Attenuate Sweet Cravings. International Journal of Endocrinology No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-1036412
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Conroy, Rushika& Febres, Gerardo& McMahon, Donald J.& Thorner, Michael O.& Gaylinn, Bruce D.& Conwell, Irene…[et al.]. Recombinant Human Leptin Does Not Alter Gut Hormone Levels after Gastric Bypass but May Attenuate Sweet Cravings. International Journal of Endocrinology. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1036412
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1036412
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)