Recombinant Human Leptin Does Not Alter Gut Hormone Levels after Gastric Bypass but May Attenuate Sweet Cravings
Joint Authors
Conroy, Rushika
Febres, Gerardo
McMahon, Donald J.
Thorner, Michael O.
Gaylinn, Bruce D.
Conwell, Irene
Aronne, Louis
Korner, Judith
Source
International Journal of Endocrinology
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-08
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Bariatric surgery improves glucose homeostasis and alters gut hormones partly independent of weight loss.
Leptin plays a role in these processes; levels are decreased following bariatric surgery, creating a relative leptin insufficiency.
We previously showed that leptin administration in a weight-reduced state after Roux-en-Y gastric bypass (RYGB) caused no further weight loss.
Here, we discuss the impact of leptin administration on gut hormones, glucostasis, and appetite.
Weight stable women after RYGB were randomized to receive placebo or recombinant human metreleptin (0.05 mg/kg twice daily).
At weeks 0 and 16, a liquid meal challenge was performed.
Glucose, insulin, C-peptide, GLP-1, PYY, glucagon, and ghrelin (total, acyl, and desacyl) were measured fasting and postprandially.
Appetite was assessed using a visual analog scale.
Mean post-op period was 53 ± 2.3 months; mean BMI was 34.6 ± 0.2 kg/m2.
At 16 weeks, there was no significant change in weight within or between groups.
Fasting PYY was significantly different between groups and the leptin group had lower sweets craving at week 16 than the placebo group ( P < 0.05 ).
No other differences were observed.
Leptin replacement does not alter gut hormones or glucostasis but may diminish sweet cravings compared to placebo in this population of post-RYGB women.
American Psychological Association (APA)
Conroy, Rushika& Febres, Gerardo& McMahon, Donald J.& Thorner, Michael O.& Gaylinn, Bruce D.& Conwell, Irene…[et al.]. 2014. Recombinant Human Leptin Does Not Alter Gut Hormone Levels after Gastric Bypass but May Attenuate Sweet Cravings. International Journal of Endocrinology،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1036412
Modern Language Association (MLA)
Conroy, Rushika…[et al.]. Recombinant Human Leptin Does Not Alter Gut Hormone Levels after Gastric Bypass but May Attenuate Sweet Cravings. International Journal of Endocrinology No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-1036412
American Medical Association (AMA)
Conroy, Rushika& Febres, Gerardo& McMahon, Donald J.& Thorner, Michael O.& Gaylinn, Bruce D.& Conwell, Irene…[et al.]. Recombinant Human Leptin Does Not Alter Gut Hormone Levels after Gastric Bypass but May Attenuate Sweet Cravings. International Journal of Endocrinology. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1036412
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1036412