Enucleation-Induced Rat Adrenal Gland Regeneration: Expression Profile of Selected Genes Involved in Control of Adrenocortical Cell Proliferation
المؤلفون المشاركون
Ruciński, Marcin
Malendowicz, Ludwik K.
Tyczewska, Marianna
Ziolkowska, Agnieszka
Szyszka, Marta
Trejter, Marcin
Hochol-Molenda, Anna
Nowak, Krzysztof W.
المصدر
International Journal of Endocrinology
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-11-06
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
Enucleation-induced adrenal regeneration is a highly controlled process; however, only some elements involved in this process have been recognized.
Therefore, we performed studies on regenerating rat adrenals.
Microarray RNA analysis and QPCR revealed that enucleation resulted in a rapid elevation of expression of genes involved in response to wounding, defense response, and in immunological processes.
Factors encoded by these genes obscure possible priming effects of various cytokines on initiation of regeneration.
In regenerating adrenals we identified over 100 up- or downregulated genes involved in adrenocortical cell proliferation.
The changes were most significant at days 2-3 after enucleation and their number decreased during regeneration.
For example, expression analysis revealed a notable upregulation of the growth arrest gene, Gadd45, only 24 hours after surgery while expression of cyclin B1 and Cdk1 genes was notably elevated between days 1–8 of regeneration.
These changes were accompanied by changes in expression levels of numerous growth factors and immediate-early transcription factors genes.
Despite notable differences in mechanisms of adrenal and liver regeneration, in regenerating adrenals we identified genes, the expression of which is well recognized in regenerating liver.
Thus, it seems legitimate to suggest that, in the rat, the general model of liver and adrenal regeneration demonstrate some degree of similarity.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Tyczewska, Marianna& Ruciński, Marcin& Ziolkowska, Agnieszka& Szyszka, Marta& Trejter, Marcin& Hochol-Molenda, Anna…[et al.]. 2014. Enucleation-Induced Rat Adrenal Gland Regeneration: Expression Profile of Selected Genes Involved in Control of Adrenocortical Cell Proliferation. International Journal of Endocrinology،Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-1036413
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Tyczewska, Marianna…[et al.]. Enucleation-Induced Rat Adrenal Gland Regeneration: Expression Profile of Selected Genes Involved in Control of Adrenocortical Cell Proliferation. International Journal of Endocrinology No. 2014 (2014), pp.1-13.
https://search.emarefa.net/detail/BIM-1036413
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Tyczewska, Marianna& Ruciński, Marcin& Ziolkowska, Agnieszka& Szyszka, Marta& Trejter, Marcin& Hochol-Molenda, Anna…[et al.]. Enucleation-Induced Rat Adrenal Gland Regeneration: Expression Profile of Selected Genes Involved in Control of Adrenocortical Cell Proliferation. International Journal of Endocrinology. 2014. Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-1036413
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1036413
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر