Resveratrol Prevention of Diabetic Nephropathy is Associated with the Suppression of Renal Inflammation and Mesangial Cell Proliferation: Possible Roles of AktNF- κ B Pathway
المؤلفون المشاركون
Yuan, Hang
Sun, Jing
Cui, Wen-peng
Xu, Feng
Wang, Yuehui
Wu, Man
Guo, Qiaoyan
Kong, Lili
Wu, Hao
Miao, Lining
المصدر
International Journal of Endocrinology
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-02-09
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
The present study was to investigate the protection of resveratrol (RSV) in diabetes associated with kidney inflammation and cell proliferation.
Rat mesangial cell and streptozotocin-induced type 1 diabetes mouse model were used.
In vitro, RSV attenuated high glucose-induced plasminogen activator inhibitor (PAI-1) expression and mesangial cell proliferation, as well as Akt and nuclear factor-kappa B (NF-κB) activation.
The similar results were recaptured in the experiment with Akt inhibitors.
In vivo, mice were divided into three groups: control group, diabetes mellitus (DM) group, and RSV-treated DM group.
Compared with control group, the kidney weight to body weight ratio and albumin to creatinine ratio were increased in DM group, but not in RSV-treated DM group.
Furthermore, the increased expression of PAI-1 and intercellular adhesion molecule-1 in diabetic renal cortex were also reduced by RSV administration.
Besides, the kidney p-Akt/Akt ratio and NF-κB were significantly increased in DM group; however, these changes were reversed in RSV-treated DM group.
Additionally, immunohistochemistry results indicated that RSV treatment reduced the density of proliferating cell nuclear antigen-positive cells significantly in glomeruli of diabetic mice.
These results suggest that RSV prevents diabetes-induced renal inflammation and mesangial cell proliferation possibly through Akt/NF-κB pathway inhibition.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Xu, Feng& Wang, Yuehui& Cui, Wen-peng& Yuan, Hang& Sun, Jing& Wu, Man…[et al.]. 2014. Resveratrol Prevention of Diabetic Nephropathy is Associated with the Suppression of Renal Inflammation and Mesangial Cell Proliferation: Possible Roles of AktNF- κ B Pathway. International Journal of Endocrinology،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1036449
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Xu, Feng…[et al.]. Resveratrol Prevention of Diabetic Nephropathy is Associated with the Suppression of Renal Inflammation and Mesangial Cell Proliferation: Possible Roles of AktNF- κ B Pathway. International Journal of Endocrinology No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-1036449
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Xu, Feng& Wang, Yuehui& Cui, Wen-peng& Yuan, Hang& Sun, Jing& Wu, Man…[et al.]. Resveratrol Prevention of Diabetic Nephropathy is Associated with the Suppression of Renal Inflammation and Mesangial Cell Proliferation: Possible Roles of AktNF- κ B Pathway. International Journal of Endocrinology. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1036449
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1036449
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر